Kageyama K, Nagasawa T, Kimura S, Kobayashi T, Kinoshita Y
Can J Biochem. 1980 Jun;58(6):504-8. doi: 10.1139/o80-068.
Cytotoxic activities of unsaturated fatty acids against lymphocytes were studied by demonstrating the inhibition of RNA synthetic activity of incubated lymphocytes. In general, the cytotoxic activity of fatty acids increases with decreasing number of carbon atoms and increasing number of double bonds. An empirical formula predicting the degree of impairment of lymphocytes by various fatty acids was proposed. Furthermore, protective effects of serum on cytotoxic actions of unsaturated fatty acids to lymphocytes were studied and the significance of these findings was discussed.
通过证明对培养淋巴细胞RNA合成活性的抑制作用，研究了不饱和脂肪酸对淋巴细胞的细胞毒性活性。一般来说，脂肪酸的细胞毒性活性随着碳原子数的减少和双键数的增加而增强。提出了一个预测各种脂肪酸对淋巴细胞损伤程度的经验公式。此外，还研究了血清对不饱和脂肪酸对淋巴细胞细胞毒性作用的保护作用，并讨论了这些发现的意义。
