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1
H-2-restricted helper factor secreted by clone hybridoma cells.克隆杂交瘤细胞分泌的H-2限制性辅助因子。
J Exp Med. 1981 Sep 1;154(3):942-51. doi: 10.1084/jem.154.3.942.
2
Two separate genes regulate self-Ia and carrier recognition in H-2-restricted helper factors secreted by hybridoma cells.两个独立的基因调控杂交瘤细胞分泌的H-2限制性辅助因子中的自身Ia和载体识别。
J Exp Med. 1981 Dec 1;154(6):1910-21. doi: 10.1084/jem.154.6.1910.
3
IgM induction in murine B hybridomas with Ia-restricted T cell clones: a monoclonal model for T and B cell interactions in antibody response.用Ia限制的T细胞克隆在小鼠B杂交瘤中诱导IgM：抗体应答中T细胞与B细胞相互作用的单克隆模型。
Microbiol Immunol. 1985;29(10):993-1003. doi: 10.1111/j.1348-0421.1985.tb02963.x.
4
Specific lymphocyte-target cell conjugate formation between tumor-specific helper T-cell hybridomas and IA-bearing RCS tumors and IE-bearing allogeneic cells. I. Role of Ia and both L3T4 and LFA-1 antigens in recognition/binding.肿瘤特异性辅助性T细胞杂交瘤与携带IA的RCS肿瘤及携带IE的同种异体细胞之间特异性淋巴细胞-靶细胞共轭体的形成。I. Ia以及L3T4和LFA-1抗原在识别/结合中的作用。
J Immunol. 1986 Dec 1;137(11):3681-8.
5
H-2-restricted antigen binding by a hybridoma clone that produces antigen-specific helper factor.产生抗原特异性辅助因子的杂交瘤克隆的H-2限制性抗原结合
Proc Natl Acad Sci U S A. 1981 Jan;78(1):549-53. doi: 10.1073/pnas.78.1.549.
6
The molecular basis of T helper cell function--I. Allotype- and MHC-linked determinants on antigen-specific, H-2-restricted T cell lines, hybridomas and lymphomas.
Mol Immunol. 1984 Oct;21(10):915-28. doi: 10.1016/0161-5890(84)90148-2.
7
Antigen-specific, H-2-restricted helper T cell hybridomas.抗原特异性、H-2限制的辅助性T细胞杂交瘤。
J Exp Med. 1982 Jul 1;156(1):191-204. doi: 10.1084/jem.156.1.191.
8
Characteristics of a poly(LTyr,LGlu)-poly(DLAla)--poly(LLys)-specific helper factor derived from a T cell hybridoma.源自T细胞杂交瘤的聚（L-酪氨酸，L-谷氨酸）-聚（D-丙氨酸）-聚（L-赖氨酸）特异性辅助因子的特性
Eur J Immunol. 1981 Nov;11(11):931-6. doi: 10.1002/eji.1830111115.
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Analysis of T hybridomas prepared from a T cell clone with three specificities. Recognition of self + X and allo-H-2 determinants segregates from recognition of Mlsa determinants.对由具有三种特异性的T细胞克隆制备的T杂交瘤的分析。对自身+X和同种异体H-2决定簇的识别与对Mlsa决定簇的识别相分离。
J Immunol. 1988 Sep 15;141(6):1828-34.
10
The role of Ia molecules in the activation of T lymphocytes. I. The activation of an IL 1-dependent IL 2-producing T cell hybridoma by Con A requires an interaction, which is not H-2-restricted, with an Ia-bearing accessory cell.Ia分子在T淋巴细胞激活中的作用。I. 伴刀豆球蛋白A激活IL-1依赖的产生IL-2的T细胞杂交瘤需要与表达Ia的辅助细胞进行非H-2限制性的相互作用。
J Immunol. 1982 Oct;129(4):1360-6.

引用本文的文献

1
Inhibition by Fab and Fab'2 monoclonal anti-Ia antibody fragments of T-lymphocyte proliferative responses.Fab和Fab'2单克隆抗Ia抗体片段对T淋巴细胞增殖反应的抑制作用。
Immunology. 1982 Jul;46(3):533-44.
2
Human T cell hybridomas secreting immune interferon.分泌免疫干扰素的人T细胞杂交瘤
Proc Natl Acad Sci U S A. 1982 Dec;79(24):7857-61. doi: 10.1073/pnas.79.24.7857.
3
Characterization of a human X mouse T cell hybridoma and identification of a clone secreting and binding interleukin-2.人X小鼠T细胞杂交瘤的特性鉴定及分泌并结合白细胞介素-2的克隆的鉴定。
Immunology. 1984 May;52(1):117-28.
4
The role of products of the human HLA-DR locus (Ia molecules) in in vitro M. leprae driven lymphoproliferation.人类HLA - DR基因座产物（Ia分子）在体外麻风杆菌驱动的淋巴细胞增殖中的作用。
Clin Exp Immunol. 1983 Aug;53(2):328-34.
5
Retention and loss of immunoglobulin heavy chain alleles in helper T cell hybridoma clones.辅助性T细胞杂交瘤克隆中免疫球蛋白重链等位基因的保留与丢失
EMBO J. 1983;2(5):781-6. doi: 10.1002/j.1460-2075.1983.tb01500.x.
6
Genetic chasing of T helper cell idiotype and allotype genes.T辅助细胞独特型和同种异型基因的遗传追踪
Immunogenetics. 1982;16(3):229-41. doi: 10.1007/BF00343312.
7
Two separate genes regulate self-Ia and carrier recognition in H-2-restricted helper factors secreted by hybridoma cells.两个独立的基因调控杂交瘤细胞分泌的H-2限制性辅助因子中的自身Ia和载体识别。
J Exp Med. 1981 Dec 1;154(6):1910-21. doi: 10.1084/jem.154.6.1910.
8
F1 mice make two species of antigen-specific, parental haplotype-restricted, T-helper factor whose restrictions correspond to the phenotype of the I-A determinants that they bear.F1小鼠产生两种抗原特异性、亲本单倍型受限的T辅助因子，其限制与它们所携带的I-A决定簇的表型相对应。
Immunology. 1987 Nov;62(3):445-50.

本文引用的文献

1
Mechanism of antigen binding by T cells. H-2(I-A)-restricted binding of antigen plus Ia by helper cells.T细胞对抗原的结合机制。辅助细胞对抗原加Ia的H-2（I-A）限制性结合。
Eur J Immunol. 1980 Apr;10(4):273-81. doi: 10.1002/eji.1830100410.
2
H-2-restricted antigen binding by a hybridoma clone that produces antigen-specific helper factor.产生抗原特异性辅助因子的杂交瘤克隆的H-2限制性抗原结合
Proc Natl Acad Sci U S A. 1981 Jan;78(1):549-53. doi: 10.1073/pnas.78.1.549.
3
Allotype-linked genetic control of a polymorphic VH framework framework determinant on mouse T-helper cell receptors.小鼠T辅助细胞受体上多态性VH框架决定簇的同种异型连锁遗传控制。
Nature. 1980 May 22;285(5762):257-9. doi: 10.1038/285257a0.
4
Preparation and characterization of anti-framework antibodies to the kappa-chain variable region (V kappa) of mouse immunoglobulins.小鼠免疫球蛋白κ链可变区（Vκ）抗构架抗体的制备与特性分析
J Immunol. 1980 Feb;124(2):691-5.
5
Alloactivated Lyt 1 +2- T lymphoblasts bind syngeneic Ia antigens.
Nature. 1980 Jun 12;285(5765):496-8. doi: 10.1038/285496a0.
6
Suppression of antibody and T cell proliferative responses to L-glutamic acid60-L-alanine30-L-tyrosine10 by a specific monoclonal T cell factor.一种特异性单克隆T细胞因子对L-谷氨酸60-L-丙氨酸30-L-酪氨酸10抗体及T细胞增殖反应的抑制作用
J Exp Med. 1980 Jul 1;152(1):235-40. doi: 10.1084/jem.152.1.235.
7
Coexistence of variable region of immunoglobulin heavy chain and I region gene products on antigen-specific suppressor T cells and suppressor T cell factor. A minimal model of functional antigen receptor of T cells.
Mol Immunol. 1980 Jul;17(7):867-75. doi: 10.1016/0161-5890(80)90035-8.
8
Antigen-specific T-cell factors.抗原特异性T细胞因子。
Immunology. 1980 Dec;41(4):759-87. doi: 10.1007/BF00199524.
9
Antigen-specific helper T cells required for dominant production of an idiotype (THId) are not under immune response (Ir) gene control.独特型（THId）优势产生所需的抗原特异性辅助性T细胞不受免疫反应（Ir）基因控制。
J Exp Med. 1980 Dec 1;152(6):1571-82. doi: 10.1084/jem.152.6.1571.
10
T-cell hybridoma bearing heavy chain variable region determinants producing (T,G)-A--L-specific helper factor.携带产生（T，G）-A--L特异性辅助因子的重链可变区决定簇的T细胞杂交瘤。
Nature. 1980 Jul 17;286(5770):270-2. doi: 10.1038/286270a0.

克隆杂交瘤细胞分泌的H-2限制性辅助因子。

H-2-restricted helper factor secreted by clone hybridoma cells.

作者信息

Lonai P, Puri J, Bitton S, Ben-Neriah Y, Givol D, Hämmerling G J

出版信息

J Exp Med. 1981 Sep 1;154(3):942-51. doi: 10.1084/jem.154.3.942.

DOI:10.1084/jem.154.3.942
PMID:6168725
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2186458/
Abstract

Biological and serological characteristics of a helper factor secreted by cloned hybridoma cells was described. The factor is carrier specific and contains determinants shared with immunoglobulin VH bu does not react with V kappa- or V lambda-specific antibodies. Presence of four H-2I-controlled antigenic specificities, Ia.ml, Ia.m2, Ia.17, and Ia.m7, was detected. Hence, it is possible that both A beta and E alpha loci may be involved in its control. Helper effect could be obtained only toward B cell sources that shared the H-2K and I-A antigens with the hybridoma cells. Similarly, the factor was absorbed only by spleen cells syngeneic in I-A. Previous studies have demonstrated that this clone binds antigen in an H-2-restricted manner. It follows that H-2-restricted helper cells produce H-2-restricted helper factors. Hence, they support the view that specific T cell factors may represent secreted T cell receptors.

摘要

描述了克隆杂交瘤细胞分泌的一种辅助因子的生物学和血清学特性。该因子具有载体特异性，含有与免疫球蛋白VH共享的决定簇，但不与Vκ或Vλ特异性抗体发生反应。检测到四种由H-2I控制的抗原特异性，即Ia.ml、Ia.m2、Ia.17和Ia.m7。因此，Aβ和Eα基因座都有可能参与其调控。辅助效应仅能作用于与杂交瘤细胞共享H-2K和I-A抗原的B细胞来源。同样，该因子仅被I-A同基因的脾细胞吸收。先前的研究表明，该克隆以H-2限制的方式结合抗原。由此可见，H-2限制的辅助细胞产生H-2限制的辅助因子。因此，它们支持特定T细胞因子可能代表分泌型T细胞受体的观点。