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相似文献

1
Induction of human antigen-specific suppressor factors in vitro.体外诱导人抗原特异性抑制因子
Clin Exp Immunol. 1981 Mar;43(3):517-25.
2
The role of macrophages in anti-idiotypic antibody and T suppressor factor induction of timothy grass pollen antigen B-specific T suppressor cells.巨噬细胞在抗独特型抗体和禾本科牧草花粉抗原B特异性抑制性T细胞诱导中的作用。
J Immunol. 1987 Aug 15;139(4):1046-53.
3
Generation of antigen-specific suppressor cells in vitro in man.人体中体外抗原特异性抑制细胞的产生
J Immunol. 1983 Sep;131(3):1209-13.
4
Regulation of timothy grass pollen IgE antibody formation. I. In-vitro induction of suppressor T cells by soluble T suppressor factors.梯牧草花粉IgE抗体形成的调节。I. 可溶性T抑制因子对抑制性T细胞的体外诱导
Immunology. 1983 Jul;49(3):463-9.
5
Sequential development of helper and suppressor functions, antibody titers and functional avidities to a streptococcal antigen in rhesus monkeys.恒河猴对链球菌抗原的辅助和抑制功能、抗体滴度及功能亲和力的顺序性发展。
Eur J Immunol. 1984 Sep;14(9):814-9. doi: 10.1002/eji.1830140909.
6
In vitro induction of HBsAg-specific CD8 CD11 human suppressor T cells.体外诱导乙肝表面抗原特异性CD8 CD11人抑制性T细胞
Immunology. 1987 Nov;62(3):431-8.
7
Induction of suppression by a murine nonspecific suppressor-inducer cell line (M1-A5). III. Partial purification of the suppressor cell-inducing factors.小鼠非特异性抑制诱导细胞系（M1-A5）诱导抑制作用。III. 抑制细胞诱导因子的部分纯化。
J Mol Cell Immunol. 1987;3(3):157-66.
8
The xenogeneic effect. I. Antigen and mitogen-stimulated human lymphocytes produce a non-antigen-specific factor which reconstitutes the antibody response of T cell-deficient mouse spleen cells.异种效应。I. 抗原和丝裂原刺激的人淋巴细胞产生一种非抗原特异性因子，该因子可重建T细胞缺陷小鼠脾细胞的抗体应答。
J Immunol. 1975 Nov;115(5):1295-1300.
9
Cells involved in the immune response. XXXVI. The thymic antigen-specific suppressor cell in the immunized rabbit is a T cell with receptors for FcG and the antigen and it acts, via a secreted suppressor factor, directly on the immune splenic AFC B cell to inhibit antibody secretion.参与免疫反应的细胞。三十六。免疫兔体内的胸腺抗原特异性抑制细胞是一种具有FcG受体和抗原受体的T细胞，它通过分泌的抑制因子直接作用于免疫脾AFC B细胞以抑制抗体分泌。
Immunology. 1988 Jun;64(2):253-9.
10
Activation of antigen-specific suppressor cells in human schistosomiasis mansoni by fractions of soluble egg antigens nonadherent to Con A sepharose.
J Immunol. 1981 Dec;127(6):2314-8.

引用本文的文献

1
A comparative study of streptococcal antigen-binding human T8+ cells and monocytes, in relation to the HLA-DRw6 locus and the helper, suppressor and contrasuppressor functions.关于HLA - DRw6基因座以及辅助、抑制和抗抑制功能，对链球菌抗原结合人T8 +细胞和单核细胞的比较研究。
Immunology. 1984 Oct;53(2):215-25.
2
Human insulin specific suppressor factors. I. Induction, characteristics and comparison to murine factors.人胰岛素特异性抑制因子。I. 诱导、特性及与鼠类因子的比较。
Clin Exp Immunol. 1982 Mar;47(3):715-24.
3
Cell-bound helper and suppressor factors in primate lymphocytes.灵长类淋巴细胞中的细胞结合辅助因子和抑制因子。
Clin Exp Immunol. 1982 Mar;47(3):706-14.
4
Structure of antigen-specific suppressor factors: current views.抗原特异性抑制因子的结构：当前观点
Surv Immunol Res. 1982;1(1):17-23. doi: 10.1007/BF02918237.
5
Characteristics of suppressor factors generated from human mononuclear cells using concanavalin A and C-reactive protein.使用伴刀豆球蛋白A和C反应蛋白从人单核细胞产生的抑制因子的特性
Clin Exp Immunol. 1983 Aug;53(2):451-7.
6
Characterization of human helper and suppressor factors with special reference to HLA-DR determinants.人类辅助因子和抑制因子的特性，特别涉及HLA - DR决定簇
Immunology. 1983 Apr;48(4):695-702.
7
Specific suppression of antibody responses in vivo. I. Effects of in vitro produced suppressor factor.体内抗体反应的特异性抑制。I. 体外产生的抑制因子的作用。
Immunology. 1982 Mar;45(3):459-65.
8
Specific suppression of anti-DNA production in vitro.体外特异性抑制抗DNA的产生。
J Clin Immunol. 1988 Sep;8(5):362-71. doi: 10.1007/BF00917152.
9
Characterization of human T8+ suppressor and contrasuppressor cells, separated by the lectin Vicia villosa.用人绒毛豌豆凝集素分离的人T8 +抑制细胞和抗抑制细胞的特性研究
Immunology. 1988 Feb;63(2):247-54.

本文引用的文献

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PREPARATION OF PURIFIED ANTI-2,4-DINITROPHENYL ANTIBODIES.纯化抗2,4-二硝基苯基抗体的制备
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2
A comparative investigation of the generation of specific T cell-helper function induced by Streptococcus mutans in monkeys and mice.变形链球菌在猴和小鼠中诱导产生特异性T细胞辅助功能的比较研究。
J Immunol. 1980 May;124(5):2384-9.
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Immunogenicity of trinitrophenyl-hemocyanin: production of primary and secondary anti-hapten precipitins.三硝基苯基-血蓝蛋白的免疫原性：一级和二级抗半抗原沉淀素的产生
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Antitrinitrophenyl (TNP) plaque assay. Primary response of Balb/c mice to soluble and particulate immunogen.抗三硝基苯基（TNP）空斑试验。Balb/c小鼠对可溶性和颗粒性免疫原的初次反应。
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T cell control of antibody production.T细胞对抗体产生的控制。
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6
A rapid method for the isolation of functional thymus-derived murine lymphocytes.一种分离功能性胸腺来源的小鼠淋巴细胞的快速方法。
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Induction of specific helper cells in vitro.体外诱导特异性辅助细胞。
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Phenotypic and functional distinctions between the TH2+ and JRA+ T cell subsets in man.人类TH2+和JRA+ T细胞亚群之间的表型和功能差异。
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Antigen-specific helper factor in man.人类抗原特异性辅助因子。
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10
Suppressors in the network of immunity.免疫网络中的抑制因子。
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体外诱导人抗原特异性抑制因子

Induction of human antigen-specific suppressor factors in vitro.

作者信息

Kontiainen S, Woody J N, Rees A, Feldmann M

出版信息

Clin Exp Immunol. 1981 Mar;43(3):517-25.

PMID:6169475
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1537186/
Abstract

Based on methods used for the in vitro induction of antigen-specific suppressor cells in the mouse, we have cultured Ficoll-Isopaque-separated human blood cells with high dose of antigen (100 microgram/ml) in Marbrook culture vessels for 4 days. The resulting cells, when further recultured for 24 hr with a low dose of antigen (1 microgram/ml), released into the supernatant material, termed 'suppressor factor', which inhibited, in an antigen-specific manner, the antibody response of mouse spleen cells in culture. The suppressor factor was analysed using immunoabsorbents, and was bound to and eluted from specific antigen, concanavalin A and lentil lectin, anti-human Ia antibodies, and anti-mouse suppressor factor antibodies, but was not bound to antibodies against human IgG.

摘要

基于用于在小鼠体内体外诱导抗原特异性抑制细胞的方法，我们将经Ficoll-Isopaque分离的人血细胞与高剂量抗原（100微克/毫升）在Marbrook培养容器中培养4天。所得细胞在与低剂量抗原（1微克/毫升）进一步再培养24小时后，释放出一种称为“抑制因子”的物质到上清液中，该抑制因子以抗原特异性方式抑制培养的小鼠脾细胞的抗体反应。使用免疫吸附剂对抑制因子进行分析，发现它能与特异性抗原、伴刀豆球蛋白A和扁豆凝集素、抗人Ia抗体以及抗小鼠抑制因子抗体结合并从其上洗脱，但不与抗人IgG抗体结合。