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人类抗原特异性辅助因子。

Antigen-specific helper factor in man.

作者信息

Mudawwar F B, Yunis E J, Geha R S

出版信息

J Exp Med. 1978 Oct 1;148(4):1032-43. doi: 10.1084/jem.148.4.1032.

DOI:10.1084/jem.148.4.1032
PMID:359749
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2185019/
Abstract

Supernates of tetanus toxoid (TT) antigen-stimulated human T cells were studied for the presence of an antigen-specific T-cell helper factor (ASF). Supernates were circulated over an immunosorbent column consisting of insolubilized TT antigen. The material which bound to the column was eluted with 3 M NaCNS and was shown to contain a factor which in the presence of TT-induced specific IgG anti-TT antibody synthesis in autologous B cells without causing readily detectable proliferation. ASF activity was partially inhibited by antisera directed against the B-cell alloantigens of the ASF donor. Immunosorbent columns containing such antisera removed ASF activity. Immunosorbent columns containing antisera to human immunoglobulin heavy chain determinants did not remove ASF activity; whereas immunosorbent columns containing rabbit idiotypic antiserum directed against anti-TT antibodies completely removed ASF activity. ASF was destroyed by treatment with proteolytic enzymes; its molecular weight was estimated by Sephadex G-100 gel column chromatography to be between 25,000 and 75,000 daltons.

摘要

研究了破伤风类毒素（TT）抗原刺激的人T细胞的上清液中是否存在抗原特异性T细胞辅助因子（ASF）。将上清液通过由不溶性TT抗原组成的免疫吸附柱循环。与柱结合的物质用3M NaCNS洗脱，结果显示其中含有一种因子，该因子在TT存在的情况下可诱导自体B细胞合成特异性IgG抗TT抗体，且不会引起易于检测到的增殖。针对ASF供体的B细胞同种异体抗原的抗血清可部分抑制ASF活性。含有此类抗血清的免疫吸附柱可去除ASF活性。含有抗人免疫球蛋白重链决定簇抗血清的免疫吸附柱不会去除ASF活性；而含有针对抗TT抗体的兔独特型抗血清的免疫吸附柱可完全去除ASF活性。ASF经蛋白水解酶处理后被破坏；通过Sephadex G - 100凝胶柱色谱法估计其分子量在25,000至75,000道尔顿之间。

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本文引用的文献

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Studies of 125I trace labeling of immunoglobulin G by chloramine-T.用氯胺 - T对免疫球蛋白G进行¹²⁵I微量标记的研究。
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Antigen-specific T-cell factor in cell cooperation: physical properties and mapping in the left-hand (K) half of H-2.细胞协作中的抗原特异性T细胞因子：物理性质及在H-2左手（K）半区的定位
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Interaction of human thymus-derived and non-thymus-derived lymphocytes in vitro. Induction of proliferation and antibody synthesis in B lymphocytes by a soluble factor released from antigen-stimulated T lymphocytes.人胸腺来源与非胸腺来源淋巴细胞的体外相互作用。抗原刺激的T淋巴细胞释放的可溶性因子诱导B淋巴细胞增殖和抗体合成。
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Sheep red cell binding to human lymphocytes treated with neuraminidase; enhancement of T cell binding and identification of a subpopulation of B cells.绵羊红细胞与经神经氨酸酶处理的人淋巴细胞的结合；T细胞结合的增强及B细胞亚群的鉴定
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8
Antigen-specific T-cell factor in cell cooperation. Mapping within the I region of the H-2 complex and ability to cooperate across allogeneic barriers.细胞协作中的抗原特异性T细胞因子。在H-2复合体I区内的定位及跨越同种异体屏障进行协作的能力。
J Exp Med. 1975 Sep 1;142(3):694-700. doi: 10.1084/jem.142.3.694.
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Antigen-specific and nonspecific mediators of T cell/B cell cooperation. I. Evidence for their production by different T cells.T细胞/B细胞协作的抗原特异性和非特异性介质。I. 不同T细胞产生这些介质的证据。
J Immunol. 1975 Mar;114(3):1116-25.
10
Second genetic locus in the HLA region for human B-cell alloantigens.人类B细胞同种异体抗原在HLA区域的第二个基因座。
Nature. 1976 Jan 15;259(5539):145-6. doi: 10.1038/259145a0.

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