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相似文献

1
Antigen-specific helper factor in man.人类抗原特异性辅助因子。
J Exp Med. 1978 Oct 1;148(4):1032-43. doi: 10.1084/jem.148.4.1032.
2
The specificity of T-cell helper factor in man.人类T细胞辅助因子的特异性。
J Exp Med. 1977 Jun 1;145(6):1436-48. doi: 10.1084/jem.145.6.1436.
3
Idiotypic determinants on human T cells and modulation of human T cell responses by anti-idiotypic antibodies.人类T细胞上的独特型决定簇以及抗独特型抗体对人类T细胞应答的调节。
J Immunol. 1984 Oct;133(4):1846-51.
4
Mechanisms of the failure of resting B cells to present tetanus toxoid antigen to T cells.静息B细胞向T细胞呈递破伤风类毒素抗原失败的机制。
J Immunol. 1984 Mar;132(3):1144-50.
5
Macrophage T cell interaction in man: binding of antigen-specific human proliferating and helper T cells to antigen-pulsed macrophages.人类巨噬细胞与T细胞的相互作用：抗原特异性人类增殖性T细胞和辅助性T细胞与抗原刺激的巨噬细胞的结合。
J Immunol. 1981 Feb;126(2):781-6.
6
Presence of circulating anti-idiotype-bearing cells after booster immunization with tetanus toxoid (TT) and inhibition of anti-TT antibody synthesis by auto-anti-idiotypic antibody.破伤风类毒素（TT）加强免疫后循环中抗独特型细胞的存在以及自身抗独特型抗体对抗TT抗体合成的抑制作用。
J Immunol. 1983 Apr;130(4):1634-9.
7
Activation of human B lymphocytes: frequency of antigen-specific B cells triggered by alloreactive or by antigen-specific T cell clones.人B淋巴细胞的激活：同种反应性或抗原特异性T细胞克隆触发的抗原特异性B细胞频率。
Eur J Immunol. 1983 Sep;13(9):733-8. doi: 10.1002/eji.1830130908.
8
Antigen-specific antibody responses of lymphocytes to tetanus toxoid after human marrow transplantation.人类骨髓移植后淋巴细胞对破伤风类毒素的抗原特异性抗体反应。
Transplantation. 1986 May;41(5):587-92. doi: 10.1097/00007890-198605000-00007.
9
Shared idiotypic determinants on B and T lymphocytes reactive against the same antigenic determinants. I. Demonstration of similar or identical idiotypes on IgG molecules and T-cell receptors with specificity for the same alloantigens.针对相同抗原决定簇产生反应的B淋巴细胞和T淋巴细胞上共享的独特型决定簇。I. 对相同同种异体抗原有特异性的IgG分子和T细胞受体上相似或相同独特型的证明。
J Exp Med. 1975 Jul 1;142(1):197-211. doi: 10.1084/jem.142.1.197.
10
The induction and suppression of in vitro IgG anti-tetanus toxoid antibody synthesis by human lymphocytes stimulated with tetanus toxoid in the absence of in vivo booster immunizations.在无体内加强免疫的情况下，破伤风类毒素刺激人淋巴细胞对体外IgG抗破伤风类毒素抗体合成的诱导与抑制
J Immunol. 1985 Jul;135(1):185-91.

引用本文的文献

1
Immunoglobulin production induced in vitro by glucocorticoid hormones: T cell-dependent stimulation of immunoglobulin production without B cell proliferation in cultures of human peripheral blood lymphocytes.糖皮质激素在体外诱导的免疫球蛋白产生：人外周血淋巴细胞培养中不依赖B细胞增殖的T细胞依赖性免疫球蛋白产生刺激。
J Clin Invest. 1981 Dec;68(6):1539-47. doi: 10.1172/jci110408.
2
Characterization of polymyositis infiltrates using monoclonal antibodies to human leucocyte antigens.使用针对人类白细胞抗原的单克隆抗体对多发性肌炎浸润进行特征分析。
Clin Exp Immunol. 1981 Aug;45(2):290-8.
3
Partial characterization of murine and monkey helper factor to a streptococcal antigen.针对链球菌抗原的小鼠和猴辅助因子的部分特性分析。
Immunology. 1980 Nov;41(3):587-96.
4
Human anti-tetanus antibody response in vitro: autologous and allogeneic T cells provide help by different routes.人抗破伤风抗体的体外应答：自体和异体T细胞通过不同途径提供辅助。
Clin Exp Immunol. 1981 Oct;46(1):171-7.
5
Antigen B-specific helper factor from timothy grass pollen: isolation and partial characterization.梯牧草花粉中的抗原B特异性辅助因子：分离与部分特性鉴定
Immunology. 1981 Oct;44(2):373-9.
6
In vitro antibody response of human lymphocytes.人淋巴细胞的体外抗体反应。
Springer Semin Immunopathol. 1980 May;3(1):63-92. doi: 10.1007/BF00199926.
7
Non-specific factor enhancement of human in vitro antigen-dependent antibody synthesis: role of B cell activation and T cell help.人体外抗原依赖性抗体合成的非特异性因子增强作用：B细胞活化和T细胞辅助的作用
Immunology. 1984 Apr;51(4):783-91.
8
The interaction of specific T-cell help and non-specific B-cell growth factors in the production of anti-tetanus antibody by human B cells grown in serum-free microcultures.在无血清微培养中生长的人B细胞产生抗破伤风抗体过程中特定T细胞辅助因子与非特异性B细胞生长因子的相互作用。
Immunology. 1983 Nov;50(3):377-85.
9
Human B cell growth factors overcome T cell-mediated inhibition of specific antibody production: a possible mechanism for the exacerbation of autoimmune disease.人B细胞生长因子克服T细胞介导的特异性抗体产生抑制：自身免疫性疾病恶化的一种可能机制。
Clin Exp Immunol. 1983 Jun;52(3):635-40.
10
Synthesis of antibodies to hepatitis B virus by cultured lymphocytes from chronic hepatitis B surface antigen carriers.慢性乙型肝炎表面抗原携带者培养淋巴细胞合成抗乙型肝炎病毒抗体。
J Clin Invest. 1983 May;71(5):1104-13. doi: 10.1172/jci110860.

本文引用的文献

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Studies of 125I trace labeling of immunoglobulin G by chloramine-T.用氯胺 - T对免疫球蛋白G进行¹²⁵I微量标记的研究。
Immunochemistry. 1970 Nov;7(11):885-98. doi: 10.1016/0019-2791(70)90051-0.
2
Antigen-specific T-cell factor in cell cooperation: physical properties and mapping in the left-hand (K) half of H-2.细胞协作中的抗原特异性T细胞因子：物理性质及在H-2左手（K）半区的定位
J Exp Med. 1974 Dec 1;140(6):1579-87. doi: 10.1084/jem.140.6.1579.
3
A rapid method for the isolation of functional thymus-derived murine lymphocytes.一种分离功能性胸腺来源的小鼠淋巴细胞的快速方法。
Eur J Immunol. 1973 Oct;3(10):645-9. doi: 10.1002/eji.1830031011.
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Replacement of T-cell function by a T-cell product.用一种T细胞产物替代T细胞功能。
Nat New Biol. 1972 May 3;237(70):15-7. doi: 10.1038/newbio237015a0.
5
Interaction of human thymus-derived and non-thymus-derived lymphocytes in vitro. Induction of proliferation and antibody synthesis in B lymphocytes by a soluble factor released from antigen-stimulated T lymphocytes.人胸腺来源与非胸腺来源淋巴细胞的体外相互作用。抗原刺激的T淋巴细胞释放的可溶性因子诱导B淋巴细胞增殖和抗体合成。
J Exp Med. 1973 Nov 1;138(5):1230-47. doi: 10.1084/jem.138.5.1230.
6
Chromic chloride: a coupling reagent for passive hemagglutination reactions.氯化铬：一种用于被动血凝反应的偶联试剂。
J Immunol. 1967 Nov;99(5):859-66.
7
Sheep red cell binding to human lymphocytes treated with neuraminidase; enhancement of T cell binding and identification of a subpopulation of B cells.绵羊红细胞与经神经氨酸酶处理的人淋巴细胞的结合；T细胞结合的增强及B细胞亚群的鉴定
J Exp Med. 1973 Jun 1;137(6):1532-7. doi: 10.1084/jem.137.6.1532.
8
Antigen-specific T-cell factor in cell cooperation. Mapping within the I region of the H-2 complex and ability to cooperate across allogeneic barriers.细胞协作中的抗原特异性T细胞因子。在H-2复合体I区内的定位及跨越同种异体屏障进行协作的能力。
J Exp Med. 1975 Sep 1;142(3):694-700. doi: 10.1084/jem.142.3.694.
9
Antigen-specific and nonspecific mediators of T cell/B cell cooperation. I. Evidence for their production by different T cells.T细胞/B细胞协作的抗原特异性和非特异性介质。I. 不同T细胞产生这些介质的证据。
J Immunol. 1975 Mar;114(3):1116-25.
10
Second genetic locus in the HLA region for human B-cell alloantigens.人类B细胞同种异体抗原在HLA区域的第二个基因座。
Nature. 1976 Jan 15;259(5539):145-6. doi: 10.1038/259145a0.

人类抗原特异性辅助因子。

Antigen-specific helper factor in man.

作者信息

Mudawwar F B, Yunis E J, Geha R S

出版信息

J Exp Med. 1978 Oct 1;148(4):1032-43. doi: 10.1084/jem.148.4.1032.

DOI:10.1084/jem.148.4.1032
PMID:359749
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2185019/
Abstract

Supernates of tetanus toxoid (TT) antigen-stimulated human T cells were studied for the presence of an antigen-specific T-cell helper factor (ASF). Supernates were circulated over an immunosorbent column consisting of insolubilized TT antigen. The material which bound to the column was eluted with 3 M NaCNS and was shown to contain a factor which in the presence of TT-induced specific IgG anti-TT antibody synthesis in autologous B cells without causing readily detectable proliferation. ASF activity was partially inhibited by antisera directed against the B-cell alloantigens of the ASF donor. Immunosorbent columns containing such antisera removed ASF activity. Immunosorbent columns containing antisera to human immunoglobulin heavy chain determinants did not remove ASF activity; whereas immunosorbent columns containing rabbit idiotypic antiserum directed against anti-TT antibodies completely removed ASF activity. ASF was destroyed by treatment with proteolytic enzymes; its molecular weight was estimated by Sephadex G-100 gel column chromatography to be between 25,000 and 75,000 daltons.

摘要

研究了破伤风类毒素（TT）抗原刺激的人T细胞的上清液中是否存在抗原特异性T细胞辅助因子（ASF）。将上清液通过由不溶性TT抗原组成的免疫吸附柱循环。与柱结合的物质用3M NaCNS洗脱，结果显示其中含有一种因子，该因子在TT存在的情况下可诱导自体B细胞合成特异性IgG抗TT抗体，且不会引起易于检测到的增殖。针对ASF供体的B细胞同种异体抗原的抗血清可部分抑制ASF活性。含有此类抗血清的免疫吸附柱可去除ASF活性。含有抗人免疫球蛋白重链决定簇抗血清的免疫吸附柱不会去除ASF活性；而含有针对抗TT抗体的兔独特型抗血清的免疫吸附柱可完全去除ASF活性。ASF经蛋白水解酶处理后被破坏；通过Sephadex G - 100凝胶柱色谱法估计其分子量在25,000至75,000道尔顿之间。