Bungay P M, Dedrick R L, Matthews H B
J Pharmacokinet Biopharm. 1981 Jun;9(3):309-41. doi: 10.1007/BF01059269.
Disposition of chlordecone (Kepone) in the rat is quantitated. Particular attention is devoted to the role of the intestinal tract in excretion, as well as absorption, of the parent form of the halogenated pesticide. A detailed physiological pharmacokinetic model for the GI tract is presented in which the organs are segmented into a series of well-mixed compartments representing stomach, small intestine, cecum, and large intestine. The model is applied to the early time behavior of data from the following two types of studies in the rat: (1) the movement of a nonabsorbable tracer along the GI tract, and (2) the enteric transport of parent chlordecone. Model parameter values for the gut wall permeability-area products for parent chlordecone determined for the rat are used to estimate the corresponding values for man based on scale-up considerations. The enhancement of excretion rates through use of orally administered adsorbents is discussed.
对大鼠体内十氯酮（开蓬）的处置进行了定量研究。特别关注肠道在卤代农药母体形式的排泄以及吸收中所起的作用。提出了一个详细的胃肠道生理药代动力学模型，其中各器官被划分为一系列充分混合的隔室，分别代表胃、小肠、盲肠和大肠。该模型应用于大鼠以下两种研究类型数据的早期行为：（1）不可吸收示踪剂沿胃肠道的移动，以及（2）母体十氯酮的肠道转运。根据放大考量，利用为大鼠确定的母体十氯酮肠壁渗透面积乘积的模型参数值来估算人体的相应值。讨论了通过口服吸附剂提高排泄率的问题。
