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Complex mitochondrial DNA in leukemic and normal human myeloid cells.

作者信息

Clayton D A, Vinograd J

出版信息

Proc Natl Acad Sci U S A. 1969 Apr;62(4):1077-84. doi: 10.1073/pnas.62.4.1077.

DOI:10.1073/pnas.62.4.1077
PMID:5256408
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC223617/
Abstract

Mitochondrial DNA's from the peripheral blood of 14 patients with granulocytic leukemia contained a circular dimer form. No such structure could be found in M DNA's from three patients with nonmalignant proliferations of granulocytes. The frequency of the circular dimer form is reduced upon treatment with antileukemic drugs. The above results suggest that a significant relation exists between the formation and presence of the circular dimer M DNA form and granulocytic leukemia in man.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d971/223617/8ee83b625087/pnas00106-0076-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d971/223617/8ee83b625087/pnas00106-0076-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d971/223617/8ee83b625087/pnas00106-0076-a.jpg

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本文引用的文献

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Circular dimer and catenate forms of mitochondrial DNA in human leukaemic leucocytes.人白血病白细胞中线粒体DNA的环状二聚体和连环体形式
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Catenated circular DNA molecules in HeLa cell mitochondria.HeLa细胞线粒体中的连环环状DNA分子。
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Association of leukemia and mitochondrial diseases-A review.白血病与线粒体疾病的关联——综述
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Mitochondrial ROS in cancer: initiators, amplifiers or an Achilles' heel?线粒体 ROS 在癌症中的作用：启动子、放大器还是致命弱点？
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A review of the mitochondrial and glycolytic metabolism in human platelets and leukocytes: implications for their use as bioenergetic biomarkers.人类血小板和白细胞中线粒体与糖酵解代谢的综述：其作为生物能量生物标志物的应用意义
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The role of mitochondrial DNA damage and repair in the resistance of BCR/ABL-expressing cells to tyrosine kinase inhibitors.线粒体 DNA 损伤与修复在 BCR/ABL 表达细胞对酪氨酸激酶抑制剂耐药中的作用。
Int J Mol Sci. 2013 Aug 7;14(8):16348-64. doi: 10.3390/ijms140816348.
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Occurrence of complex mitochondrial DNA in normal tissues.正常组织中复杂线粒体DNA的出现。
Nature. 1968 Dec 7;220(5171):976-9. doi: 10.1038/220976a0.
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Cellular membranes and tumor behavior: a new hypothesis.细胞膜与肿瘤行为：一个新假说。
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