消胆胺：作为一种治疗十氯酮（开蓬）中毒的新方法。
Cholestyramine: use as a new therapeutic approach for chlordecone (kepone) poisoning.
作者信息
Boylan J J, Egle J L, Guzelian P S
出版信息
Science. 1978 Feb 24;199(4331):893-5. doi: 10.1126/science.74852.
PMID:74852
Abstract
In rats, as reported in humans, chlordecone (Kepone) is excreted predominantly in the feces. Cholestyramine, an anion exchange resin, binds chlordecone in rat intestine, increases its excretion into the feces, and decreases its content in the tissues. The resin appears to offer a practical method for treating chronic poisoning with this and possibly with other lipophilic toxins.
摘要
正如在人类身上所报道的那样，在大鼠中，开蓬（十氯酮）主要通过粪便排出。阴离子交换树脂消胆胺在大鼠肠道中与开蓬结合，增加其粪便排泄量，并降低其在组织中的含量。这种树脂似乎为治疗这种以及可能的其他亲脂性毒素的慢性中毒提供了一种实用方法。
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