人类衰老的免疫学研究。II. 抗RNA和抗DNA抗体的相关增加。
Immunological studies in human ageing. II. Associated increase in anti-RNA and anti-DNA antibodies.
作者信息
Schuller E, Allinquant B, Reboul J, Fournier C, Dardenne M, Bach J F
出版信息
J Clin Lab Immunol. 1981 Sep;6(2):107-10.
PMID:6169836
Abstract
Antibodies against nucleic acids have been studied by counter-immunoelectrophoresis in 95 aged subjects. Increased levels of anti-DNA and/or anti-RNA antibodies were found in 74% of the cases, and immune complexes were detected in 21% of the cases. The increase of anti-DNA antibodies was correlated with that of rheumatoid factor and increased serum IgG levels, whereas the increase of anti-RNA antibodies was associated with decreased serum IgM level and decreased lymphocyte response to PHA.
摘要
采用对流免疫电泳法对95名老年受试者的核酸抗体进行了研究。在74%的病例中发现抗DNA和/或抗RNA抗体水平升高，21%的病例检测到免疫复合物。抗DNA抗体的增加与类风湿因子的增加及血清IgG水平升高相关，而抗RNA抗体的增加与血清IgM水平降低及淋巴细胞对PHA的反应降低有关。
Zotero 插件