Reddy E P, Smith M J, Aaronson S A
Science. 1981 Oct 23;214(4519):445-50. doi: 10.1126/science.6170110.
The complete nucleotide sequence of a mammalian transforming retrovirus. Moloney murine sarcoma virus, has been determined. MSV, recombinant virus derived of helper viral and cellular sequences, possesses termini resembling prokaryotic transposable elements. The viral genome has the coding capacity for the Moloney murine leukemia virus gag gene product and contains large deletions in pol and env genes. A large open reading frame encompassing its cell-derived sequences codes for its putative transforming protein. The nature of some of the important domains in the viral genome has been established, and their structure is discussed in relation to their function.
一种哺乳动物转化逆转录病毒——莫洛尼鼠肉瘤病毒（Moloney murine sarcoma virus，MSV）的完整核苷酸序列已被确定。MSV是一种由辅助病毒序列和细胞序列组成的重组病毒，其末端类似于原核转座元件。该病毒基因组具有编码莫洛尼鼠白血病病毒gag基因产物的能力，并且在pol和env基因中存在大片段缺失。一个包含其细胞来源序列的大开放阅读框编码其假定的转化蛋白。病毒基因组中一些重要结构域的性质已经明确，并对其结构与功能的关系进行了讨论。
