Bellet D, Caillaud J M, Droz J P, Delarue J C, Bohuon C
Nouv Presse Med. 1981 Nov 7;10(40):3293-7.
Repeated measurements of serum chrionic gonadotrophic hormone (CGH), of its beta sub-unit (beta CGH) and of alpha-foetoprotein (aFP) were performed in 200 patients with germinal tumours of the testis. CGH levels were found to be high in 43,5% of patients, particularly those with choriocarcinoma (a rare tumour) or with embryonal carcinoma with syncytiotrophoblastic (ST) cells. They were also high in 24% of patients with histologically pure seminoma, which throws doubts on the homogeneity of this group of tumours and raises problems concerning their treatment in patients with high CGH. aFP levels were increased in 38% of all patients, particularly those with ST cell embryonal carcinoma (62%) or with malignant teratoma (56%). These biochemical markers may point to a histological diagnosis. They also have prognostic value and are essential for monitoring during treatment. Pre-operative assays are to particular interest and should be performed in every case.
对200例睾丸生殖细胞瘤患者进行了血清绒毛膜促性腺激素（CGH）、其β亚基（β - CGH）和甲胎蛋白（aFP）的重复测量。发现43.5%的患者CGH水平较高，尤其是那些患有绒毛膜癌（一种罕见肿瘤）或伴有合体滋养层（ST）细胞的胚胎癌患者。在24%组织学上为纯精原细胞瘤的患者中CGH水平也较高，这对该组肿瘤的同质性提出了质疑，并引发了关于高CGH患者治疗的问题。38%的所有患者aFP水平升高，尤其是那些患有ST细胞胚胎癌（62%）或恶性畸胎瘤（56%）的患者。这些生化标志物可能有助于组织学诊断。它们也具有预后价值，并且对于治疗期间的监测至关重要。术前检测特别有意义，应在每种情况下都进行。
