布氏锥虫不同抗原变异体表面抗原的mRNA的同源3'末端区域。
Homologous 3'-terminal regions of mRNAs for surface antigens of different antigenic variants of Trypanosoma brucei.
作者信息
Majumder H K, Boothroyd J C, Weber H
出版信息
Nucleic Acids Res. 1981 Sep 25;9(18):4745-53. doi: 10.1093/nar/9.18.4745.
Abstract
Sequences corresponding to the complete 3'-terminal regions of the messenger RNAs for three different Variant Surface Glycoproteins of Trypanosoma brucei were determined on complementary DNA inserts cloned in recombinant plasmids. The three sequences show 80-130 base pair long segments of strong (70-80%) homology at the 3' ends, whereas ther regions upstream from the last 130-140 base pairs contain no significant homology. The signal AAUAAA, present near the 3' ends of almost all known polyadenylated mRNAs of eukaryotes, does not occur in the 3'-terminal sequences of these three variants.
摘要
在克隆于重组质粒的互补DNA插入片段上，测定了布氏锥虫三种不同变异表面糖蛋白信使核糖核酸完整3'末端区域的对应序列。这三个序列在3'末端显示出80 - 130个碱基对长的强同源片段（70 - 80%），而在最后130 - 140个碱基对上游的区域没有明显同源性。几乎所有已知真核生物多聚腺苷酸化信使核糖核酸3'末端附近存在的信号AAUAAA，在这三个变异体的3'末端序列中未出现。
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本文引用的文献
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The isolation of plasmids containing DNA complementary to messenger RNA for variant surface glycoproteins of Trypanosoma brucei.含有与布氏锥虫可变表面糖蛋白信使核糖核酸互补的DNA的质粒的分离。
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