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Homologous 3'-terminal regions of mRNAs for surface antigens of different antigenic variants of Trypanosoma brucei.布氏锥虫不同抗原变异体表面抗原的mRNA的同源3'末端区域。
Nucleic Acids Res. 1981 Sep 25;9(18):4745-53. doi: 10.1093/nar/9.18.4745.
2
Cloning and characterization of DNA sequences complementary to messenger ribonucleic acids coding for the synthesis of two surface antigens of Trypanosoma brucei.克隆与布氏锥虫两种表面抗原合成相关的信使核糖核酸互补的DNA序列并进行特性分析。
Nucleic Acids Res. 1980 Dec 20;8(24):5965-81. doi: 10.1093/nar/8.24.5965.
3
Gene duplication and transposition linked to antigenic variation in Trypanosoma brucei.与布氏锥虫抗原变异相关的基因复制和转座
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4
The isolation of plasmids containing DNA complementary to messenger RNA for variant surface glycoproteins of Trypanosoma brucei.含有与布氏锥虫可变表面糖蛋白信使核糖核酸互补的DNA的质粒的分离。
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5
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6
Many trypanosome messenger RNAs share a common 5' terminal sequence.许多锥虫信使核糖核酸共享一个共同的5'末端序列。
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7
Novel expression-linked copies of the genes for variant surface antigens in trypanosomes.锥虫中可变表面抗原基因的新型表达相关拷贝。
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8
Identification of a telomeric DNA sequence in Trypanosoma brucei.布氏锥虫端粒DNA序列的鉴定。
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Two variant surface glycoproteins of Trypanosoma brucei have a conserved C-terminus.布氏锥虫的两种可变表面糖蛋白具有保守的C末端。
Nature. 1981;293(5829):230-3. doi: 10.1038/293230a0.

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The central roles of telomeres and subtelomeres in antigenic variation in African trypanosomes.端粒和亚端粒在非洲锥虫抗原变异中的核心作用。
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Analysis of a donor gene region for a variant surface glycoprotein and its expression site in African trypanosomes.非洲锥虫变异表面糖蛋白的供体基因区域及其表达位点分析。
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Position-dependent and promoter-specific regulation of gene expression in Trypanosoma brucei.布氏锥虫中基因表达的位置依赖性和启动子特异性调控
EMBO J. 1997 Dec 15;16(24):7422-31. doi: 10.1093/emboj/16.24.7422.
6
Size fractionation of Trypanosoma brucei DNA: localization of the 177-bp repeat satellite DNA and a variant surface glycoprotein gene in a mini-chromosomal DNA fraction.
Nucleic Acids Res. 1983 Jun 25;11(12):3889-901. doi: 10.1093/nar/11.12.3889.
7
Telomere conversion in trypanosomes.锥虫中的端粒转换
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8
Human adult T-cell leukemia virus: molecular cloning of the provirus DNA and the unique terminal structure.人类成人T细胞白血病病毒：前病毒DNA的分子克隆及独特的末端结构
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9
An analysis of cosmid clones of nuclear DNA from Trypanosoma brucei shows that the genes for variant surface glycoproteins are clustered in the genome.对布氏锥虫核DNA的黏粒克隆分析表明，可变表面糖蛋白基因在基因组中是成簇排列的。
Nucleic Acids Res. 1982 Oct 11;10(19):5905-23. doi: 10.1093/nar/10.19.5905.
10
Structure and expression of a Trypanosoma brucei gambiense variant specific antigen gene.布氏冈比亚锥虫变异特异性抗原基因的结构与表达
Nucleic Acids Res. 1982 May 25;10(10):3149-63. doi: 10.1093/nar/10.10.3149.

本文引用的文献

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A variant surface glycoprotein of Trypanosoma brucei synthesized with a C-terminal hydrophobic 'tail' absent from purified glycoprotein.布氏锥虫的一种可变表面糖蛋白，其合成时带有一个纯化糖蛋白中不存在的C末端疏水“尾”。
Nature. 1980 Dec 11;288(5791):624-6. doi: 10.1038/288624a0.
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The isolation of plasmids containing DNA complementary to messenger RNA for variant surface glycoproteins of Trypanosoma brucei.含有与布氏锥虫可变表面糖蛋白信使核糖核酸互补的DNA的质粒的分离。
Gene. 1980 Mar;8(4):391-417. doi: 10.1016/0378-1119(80)90043-8.
3
Variant surface glycoproteins of Trypanosoma brucei are synthesised with cleavable hydrophobic sequences at the carboxy and amino termini.布氏锥虫的变异表面糖蛋白在羧基末端和氨基末端合成时带有可切割的疏水序列。
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Gene duplication and transposition linked to antigenic variation in Trypanosoma brucei.与布氏锥虫抗原变异相关的基因复制和转座
Proc Natl Acad Sci U S A. 1981 May;78(5):2673-7. doi: 10.1073/pnas.78.5.2673.
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Sequencing end-labeled DNA with base-specific chemical cleavages.通过碱基特异性化学切割对末端标记的DNA进行测序。
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The ovalbumin gene-sequence of putative control regions.假定调控区的卵清蛋白基因序列。
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Novel expression-linked copies of the genes for variant surface antigens in trypanosomes.锥虫中可变表面抗原基因的新型表达相关拷贝。
Nature. 1980 Mar 6;284(5751):78-80. doi: 10.1038/284078a0.
8
The sequence 5'-AAUAAA-3'forms parts of the recognition site for polyadenylation of late SV40 mRNAs.序列5'-AAUAAA-3'构成了猴病毒40（SV40）晚期mRNA聚腺苷酸化识别位点的一部分。
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Cloning and sequence analysis of cDNAs encoding two distinct somatostatin precursors found in the endocrine pancreas of anglerfish.对在安康鱼内分泌胰腺中发现的两种不同生长抑素前体的编码cDNA进行克隆和序列分析。
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Glycoproteins.糖蛋白
Annu Rev Biochem. 1972;41:673-702. doi: 10.1146/annurev.bi.41.070172.003325.

布氏锥虫不同抗原变异体表面抗原的mRNA的同源3'末端区域。

Homologous 3'-terminal regions of mRNAs for surface antigens of different antigenic variants of Trypanosoma brucei.

作者信息

Majumder H K, Boothroyd J C, Weber H

出版信息

Nucleic Acids Res. 1981 Sep 25;9(18):4745-53. doi: 10.1093/nar/9.18.4745.

DOI:10.1093/nar/9.18.4745
PMID:6170939
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC327472/
Abstract

Sequences corresponding to the complete 3'-terminal regions of the messenger RNAs for three different Variant Surface Glycoproteins of Trypanosoma brucei were determined on complementary DNA inserts cloned in recombinant plasmids. The three sequences show 80-130 base pair long segments of strong (70-80%) homology at the 3' ends, whereas ther regions upstream from the last 130-140 base pairs contain no significant homology. The signal AAUAAA, present near the 3' ends of almost all known polyadenylated mRNAs of eukaryotes, does not occur in the 3'-terminal sequences of these three variants.

摘要

在克隆于重组质粒的互补DNA插入片段上，测定了布氏锥虫三种不同变异表面糖蛋白信使核糖核酸完整3'末端区域的对应序列。这三个序列在3'末端显示出80 - 130个碱基对长的强同源片段（70 - 80%），而在最后130 - 140个碱基对上游的区域没有明显同源性。几乎所有已知真核生物多聚腺苷酸化信使核糖核酸3'末端附近存在的信号AAUAAA，在这三个变异体的3'末端序列中未出现。