• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

由P物质类似物二甲基-C7诱导的位置厌恶不依赖于状态:P物质在厌恶中的作用

Place aversion induced by the substance P analogue, dimethyl-C7, is not state dependent: implication of substance P in aversion.

作者信息

Elliott P J

机构信息

Department of Experimental Psychology, Cambridge University, U.K.

出版信息

Exp Brain Res. 1988;73(2):354-6. doi: 10.1007/BF00248227.

DOI:10.1007/BF00248227
PMID:2463935
Abstract

Intraventricular infusion of the stable substance P analogue, DiMethyl-C7, was found to produce aversion in a place conditioning paradigm. This effect was independent of state dependent learning since the place aversion was also seen when the subjects were tested under the influence of the drug. A role for substance P in aversion is discussed.

摘要

在一个位置条件反射范式中,发现脑室内注入稳定的P物质类似物二甲基-C7会产生厌恶反应。这种效应与状态依赖学习无关,因为当在药物影响下对受试者进行测试时,也能观察到位置厌恶。文中讨论了P物质在厌恶反应中的作用。

相似文献

1
Place aversion induced by the substance P analogue, dimethyl-C7, is not state dependent: implication of substance P in aversion.由P物质类似物二甲基-C7诱导的位置厌恶不依赖于状态:P物质在厌恶中的作用
Exp Brain Res. 1988;73(2):354-6. doi: 10.1007/BF00248227.
2
Intra-median raphe infusions of muscimol and the substance P analogue DiMe-C7 produce hyperactivity: role of serotonin neurons.向正中缝内注入蝇蕈醇和P物质类似物DiMe-C7会产生多动:5-羟色胺能神经元的作用。
Behav Brain Res. 1987 Nov-Dec;26(2-3):139-51. doi: 10.1016/0166-4328(87)90162-8.
3
The behavioural effects of a novel substance P analogue following infusion into the ventral tegmental area or substantia nigra of rat brain.
Brain Res. 1982 Apr 22;238(1):137-52. doi: 10.1016/0006-8993(82)90777-6.
4
Locomotor activation induced in rodent by substance P and analogues. Blockade of the effect of substance P by met-enkephalin antiserum.P物质及其类似物在啮齿动物中诱导的运动激活。甲硫氨酸脑啡肽抗血清对P物质作用的阻断。
Neuropharmacology. 1984 Oct;23(10):1167-71. doi: 10.1016/0028-3908(84)90234-x.
5
Substance-P antagonists: effect on spontaneous and drug-induced locomotor activity in the rat.P物质拮抗剂:对大鼠自发和药物诱导的运动活动的影响
Neuropharmacology. 1987 May;26(5):419-22. doi: 10.1016/0028-3908(87)90021-9.
6
Substance P enhancement of inhibitory avoidance learning: mediation by the N-terminal sequence.P物质增强抑制性回避学习:由N端序列介导
Peptides. 1990 Jan-Feb;11(1):163-7. doi: 10.1016/0196-9781(90)90125-o.
7
Behavioural effects of tachykinins and related peptides.速激肽及相关肽的行为效应。
Brain Res. 1986 Aug 27;381(1):68-76. doi: 10.1016/0006-8993(86)90691-8.
8
Influence of substance P and fragments on passive avoidance behavior.P物质及其片段对被动回避行为的影响。
Experientia. 1984 Jan 15;40(1):89-91. doi: 10.1007/BF01959118.
9
Infusion of the substance P analogue, DiMe-C7, into the ventral tegmental area induces reinstatement of cocaine-seeking behaviour in rats.将P物质类似物DiMe-C7注入腹侧被盖区会诱发大鼠可卡因觅求行为的恢复。
Psychopharmacology (Berl). 2004 Dec;177(1-2):111-20. doi: 10.1007/s00213-004-1912-9. Epub 2004 May 27.
10
Positively reinforcing effects of the neurokinin substance P in the basal forebrain: mediation by its C-terminal sequence.神经激肽P物质在前脑基底的正性强化作用:由其C末端序列介导
Exp Neurol. 1992 Feb;115(2):282-91. doi: 10.1016/0014-4886(92)90063-v.

引用本文的文献

1
Serotonergic versus nonserotonergic dorsal raphe projection neurons: differential participation in reward circuitry.5-羟色胺能与非5-羟色胺能中缝背核投射神经元:在奖赏回路中的不同参与情况
Cell Rep. 2014 Sep 25;8(6):1857-1869. doi: 10.1016/j.celrep.2014.08.037. Epub 2014 Sep 18.
2
Treatment of alcohol dependence with drug antagonists of the stress response.使用应激反应药物拮抗剂治疗酒精依赖症。
Alcohol Res. 2012;34(4):516-21.
3
The role of endogenous dynorphin in ethanol-induced state-dependent CPP.内源性强啡肽在乙醇诱导的状态依赖性 CPP 中的作用。

本文引用的文献

1
Vasopressor receptor antagonist prevents behavioural effects of vasopressin.血管升压素受体拮抗剂可预防血管升压素的行为效应。
Nature. 1981 Jun 11;291(5815):491-3. doi: 10.1038/291491a0.
2
Cholecystokinin produces conditioned place-aversions, not place-preferences, in food-deprived rats: evidence against involvement in satiety.在食物匮乏的大鼠中,缩胆囊素产生的是条件性位置厌恶而非位置偏好:这一证据反驳了其参与饱腹感调节的观点。
Life Sci. 1983 May 2;32(18):2087-93. doi: 10.1016/0024-3205(83)90096-6.
3
Can aversive properties of (peripherally-injected) vasopressin account for its putative role in memory?
Behav Brain Res. 2012 Feb 1;227(1):58-63. doi: 10.1016/j.bbr.2011.10.035. Epub 2011 Oct 29.
4
The role of substance P in depression: therapeutic implications.P物质在抑郁症中的作用:治疗意义。
Dialogues Clin Neurosci. 2002 Mar;4(1):21-9. doi: 10.31887/DCNS.2002.4.1/mschwarz.
5
Translational and reverse translational research on the role of stress in drug craving and relapse.应激在药物成瘾和复吸中的作用的转化和反向转化研究。
Psychopharmacology (Berl). 2011 Nov;218(1):69-82. doi: 10.1007/s00213-011-2263-y. Epub 2011 Apr 15.
6
Pentylenetetrazol produces a state-dependent conditioned place aversion to alcohol withdrawal in mice.戊四氮导致小鼠对酒精戒断产生状态依赖性条件性位置厌恶。
Pharmacol Biochem Behav. 2010 Apr;95(2):258-65. doi: 10.1016/j.pbb.2010.02.001. Epub 2010 Feb 9.
7
Neurokinin-1 receptors (NK1R:s), alcohol consumption, and alcohol reward in mice.神经激肽-1 受体(NK1R:s)、小鼠的酒精消费和酒精奖赏。
Psychopharmacology (Berl). 2010 Mar;209(1):103-11. doi: 10.1007/s00213-010-1775-1. Epub 2010 Jan 30.
8
Translating the neuroscience of alcoholism into clinical treatments: from blocking the buzz to curing the blues.将酗酒的神经科学转化为临床治疗:从阻断兴奋到治愈忧郁。
Neurosci Biobehav Rev. 2010 Nov;35(2):334-44. doi: 10.1016/j.neubiorev.2009.11.018. Epub 2009 Nov 24.
9
Anxiolytic-like effects of the neurokinin 1 receptor antagonist GR-205171 in the elevated plus maze and contextual fear-potentiated startle model of anxiety in gerbils.神经激肽1受体拮抗剂GR - 205171在沙鼠高架十字迷宫和情境恐惧增强惊跳焦虑模型中的抗焦虑样作用
Behav Pharmacol. 2009 Oct;20(7):584-95. doi: 10.1097/FBP.0b013e32832ec594.
10
Substance P receptor antagonists in psychiatry: rationale for development and therapeutic potential.精神病学中的P物质受体拮抗剂:开发原理与治疗潜力
CNS Drugs. 2005;19(4):275-93. doi: 10.2165/00023210-200519040-00001.
Behav Brain Res. 1983 Mar;7(3):331-50. doi: 10.1016/0166-4328(83)90024-4.
4
Area postrema: site where cholecystokinin acts to decrease food intake.
Brain Res. 1984 Mar 19;295(2):345-7. doi: 10.1016/0006-8993(84)90982-x.
5
Drug reinforcement studied by the use of place conditioning in rat.通过在大鼠中使用位置条件反射来研究药物强化作用。
Brain Res. 1982 Jul 8;243(1):91-105. doi: 10.1016/0006-8993(82)91123-4.
6
Role of endogenous substance P in stress-induced activation of mesocortical dopamine neurones.内源性P物质在应激诱导的中脑皮质多巴胺神经元激活中的作用。
Nature. 1983;306(5945):791-2. doi: 10.1038/306791a0.
7
Substance P enhancement of passive and active avoidance conditioning in mice.
Pharmacol Biochem Behav. 1983 Oct;19(4):655-61. doi: 10.1016/0091-3057(83)90341-6.
8
Effects of lithium and haloperidol administration on the rat brain levels of substance P.锂和氟哌啶醇给药对大鼠脑内P物质水平的影响。
J Pharmacol Exp Ther. 1983 Mar;224(3):590-3.
9
Electron microscopic immunocytochemical localization of substance P in the area postrema of rat.
Brain Res. 1982 Jul 8;243(1):141-6. doi: 10.1016/0006-8993(82)91127-1.
10
Substance P analog, DiMe-C7: evidence for stability in rat brain and prolonged central actions.
Science. 1982 Jan 8;215(4529):188-90. doi: 10.1126/science.6171884.