用免疫小鼠脾脏的RNA诱导IgM记忆。

Induction of IgM memory with RNA from the spleens of immunized mice.

作者信息

Kodama K, Yoshida T, Shibiya T, Kurashige S, Mitsuhashi S

出版信息

Immunology. 1981 Nov;44(3):535-42.

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1554964/

Abstract

Ribonucleic acid (immune RNA, iRNA), extracted from the spleens of mice immunized with sheep red blood cells (SRBC), induced specific immunological memory. The humoral immune responses of iRNA-treated animals were compared with in vivo and in vitro primary and secondary responses, using the haemolytic plaque-forming cell (PFC) assay. IgM antibody formation was markedly higher in iRNA-treated than in any other mice. The effect of iRNA was antigen-specific and similar materials from non-immunized mice had no activity.

摘要

从用绵羊红细胞（SRBC）免疫的小鼠脾脏中提取的核糖核酸（免疫RNA，iRNA）可诱导特异性免疫记忆。使用溶血空斑形成细胞（PFC）试验，将经iRNA处理的动物的体液免疫反应与体内和体外的初次及二次反应进行了比较。经iRNA处理的小鼠中IgM抗体的形成明显高于其他任何小鼠。iRNA的作用具有抗原特异性，来自未免疫小鼠的类似物质没有活性。

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