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哺乳动物窦房结的肽能神经支配：血管活性肠肽、神经降压素、P物质。

Peptidergic innervation of the mammalian sinus nodes: vasoactive intestinal polypeptide, neurotensin, substance P.

作者信息

Weihe E, Reinecke M

出版信息

Neurosci Lett. 1981 Nov 4;26(3):283-8. doi: 10.1016/0304-3940(81)90146-4.

DOI:10.1016/0304-3940(81)90146-4
PMID:6172750
Abstract

By the use of the peroxidase--antiperoxidase (PAP) technique in the sinus node of several mammalian species, vasoactive intestinal polypeptide (VIP), neurotensin (NT) and substance P (SP) immunoreactive structures were detected. VIP and NT as well as SP immunoreactive fibers were found in close association to the vasculature. While the innervation by SP immunoreactive fibers was restricted to blood vessels, VIP and NT immunoreactive fibers and varicosities were also in contact to nodal cells. Juxtanodal intracardiac ganglia and single intranodal ganglionic cells were supplied by VIP, NT and SP immunoreactive varicosities. In addition, VIP immunoreactive perikarya were present. The results suggest an involvement of VIP, NT and SP in the regulation of sinus node blood flow, in impulse generation as well as in extrinsic and intrinsic cardiac reflex mechanisms.

摘要

通过在几种哺乳动物物种的窦房结中使用过氧化物酶-抗过氧化物酶（PAP）技术，检测到了血管活性肠肽（VIP）、神经降压素（NT）和P物质（SP）免疫反应性结构。发现VIP、NT以及SP免疫反应性纤维与脉管系统紧密相关。虽然SP免疫反应性纤维的神经支配仅限于血管，但VIP和NT免疫反应性纤维及膨体也与结细胞接触。结旁心内神经节和单个结内神经节细胞由VIP、NT和SP免疫反应性膨体供应。此外，还存在VIP免疫反应性核周体。结果表明，VIP、NT和SP参与了窦房结血流的调节、冲动产生以及心脏的外在和内在反射机制。

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