Bolin T, Sjödahl R, Sundqvist T, Tagesson C
Scand J Gastroenterol. 1981;16(7):897-901. doi: 10.3109/00365528109181820.
The interaction between lysolecithin and mucosal cells in the distal ileum has been studied. Using a rat experimental model, we determined the intestinal permeability to fluorescent dextran 3000 after exposure to different amounts of lysolecithin. At pH 7.3, lysolecithin, 10 mg/ml, significantly enhanced the transmural passage, and at pH 3.5, even 1 mg/ml markedly increased the permeability. However, when lysolecithin was incubated with homogenized mucosal cells, a rapid disappearance of the compound occurred; this was accompanied by formation of free fatty acids and minor formation of lecithin. It appears, therefore, that high concentrations of lysolecithin can impair the intestinal barrier function in the distal part of ileum but that the mucosal cells are well equipped with activities for the rapid removal of such high concentrations. This could be physiologically significant, since the mucosal cells could otherwise be faced with large amounts of lysolecithin that might facilitate the absorption of potentially antigenic and toxic compounds.
已对溶血卵磷脂与回肠远端黏膜细胞之间的相互作用进行了研究。我们使用大鼠实验模型，测定了在暴露于不同量的溶血卵磷脂后肠道对荧光葡聚糖3000的通透性。在pH 7.3时，10 mg/ml的溶血卵磷脂显著增强了跨壁通透性，而在pH 3.5时，即使是1 mg/ml也明显增加了通透性。然而，当溶血卵磷脂与匀浆的黏膜细胞一起孵育时，该化合物迅速消失；这伴随着游离脂肪酸的形成以及少量卵磷脂的形成。因此，似乎高浓度的溶血卵磷脂会损害回肠远端的肠道屏障功能，但黏膜细胞具备快速清除此类高浓度物质的活性。这可能具有生理意义，因为否则黏膜细胞可能会面临大量溶血卵磷脂，而这可能会促进潜在抗原性和毒性化合物的吸收。
