Mersich S E, Damonte E B, Coto C E
Intervirology. 1981;16(2):123-7. doi: 10.1159/000149257.
Nuclear involvement of the host cell in Junin virus (JV) replication was studied. alpha-Amanitin was shown to inhibit JV yield, and RNA synthesis in cell nuclei was found to be augmented during the eclipse period. JV infection exerted a selective effect on cellular RNA polymerase activities, when measured in purified infected nuclei. RNA polymerase I was inhibited, but RNA polymerase II was stimulated. These data support the hypothesis that RNA polymerase II is involved in arenavirus replication.
