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[肢根性假多关节炎与霍顿病。关于与 HLA 系统、乙肝病毒及β2 微球蛋白相关性的研究(作者译)]

[Rhizomelic pseudopolyarthritis and Horton's disease. A search for correlations with HLA system, HB virus and Beta 2 microglobulin (author's transl)].

作者信息

Chaouat D, Benlahrache C, Yannoutsos H, Hoffman H, Fruchart M C, Le Parc J M, Paolaggi J B, Auquier L

出版信息

Nouv Presse Med. 1982 Jan 16;11(2):101-4.

PMID:6173841
Abstract

The authors studied 31 patients with either rhizomelic pseudopolyarthritis or Horton's disease. Contrary to others, they found no significant correlation between these diseases and hepatitis B virus infection or HLA gene. However, beta 2 microglobulin assays showed that it was significantly higher in these patients than in a control population. In the absence of close correlation between beta 2 microglobulin levels and those of inflammatory proteins, it is suggested that the rise in microglobulin reflected an immunological mechanism requiring further investigation.

摘要

作者对31例患有肢根性假多关节炎或霍顿病的患者进行了研究。与其他人的研究结果相反,他们发现这些疾病与乙型肝炎病毒感染或HLA基因之间没有显著相关性。然而,β2微球蛋白检测显示,这些患者体内的β2微球蛋白水平显著高于对照组人群。由于β2微球蛋白水平与炎症蛋白水平之间缺乏密切相关性,因此有人提出,微球蛋白水平的升高反映了一种需要进一步研究的免疫机制。

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