[多种异生物质对大鼠体内14C-乙酸盐掺入胆固醇及其他脂质的影响]
[Effect of various xenobiotics on the in vivo incorporation of 14C-acetate into cholesterol and other lipids in the rat].
作者信息
Seidler H, Härtig M, Koslowski C, Ackermann H
出版信息
Acta Biol Med Ger. 1981;40(7-8):1043-52.
Effects of some xenobiotics on the incorporation in vivo of [14C]-acetate into cholesterol and other lipids of the rat DDT, HCH, polychlorinated biphenyl, chlorcholine chloride, ethylenthiourea and mixtures of these substances were given to rats with the feed for 7 days. After that the incorporation of [14C]-acetate into phospholipids, triglycerides and cholesterol was studied in liver, serum, heart and brain. The influence of the xenobiotics on the synthesis, transport and accumulation differed among the various organs and lipids. Outstanding was an increase of 14C-phospholipids, -triglycerides and -cholesterol in the heart after administration of polychlorinated biphenyl. The effects in the peripheral organs were generally more distinct than on the liver.
某些异生物质对大鼠体内[14C] - 乙酸盐掺入胆固醇及其他脂质的影响 将滴滴涕、六氯环己烷、多氯联苯、氯化胆碱、乙撑硫脲以及这些物质的混合物与饲料一起喂给大鼠7天。之后，研究了[14C] - 乙酸盐在肝脏、血清、心脏和大脑中掺入磷脂、甘油三酯和胆固醇的情况。异生物质对合成、转运和积累的影响在不同器官和脂质之间存在差异。值得注意的是，多氯联苯给药后心脏中14C - 磷脂、14C - 甘油三酯和14C - 胆固醇增加。外周器官中的影响通常比肝脏更明显。
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