Pereira M A, Herren S L, Britt A L, Khoury M M
Cancer Lett. 1982 Jan;15(1):95-101. doi: 10.1016/0304-3835(82)90081-7.
The ability of hexachlorobenzene and lindane in diethylnitrosamine (DENA) pretreated rats to enhance the incidence of gamma-glutamyltranspeptidase (GGTase)-positive foci was determined. In rats that received either DENA followed by a basal agar diet or hexachlorobenzene or lindane without prior administration of DENA, the incidence of GGTase-positive foci was negligible. When hexachlorobenzene or lindane were administered in the diet to rats that previously received a 2/3 partial hepatectomy prior to the DENA. The results suggest that hepatocarcinogenicity of hexachlorobenzene and lindane results from tumor promotion.
测定了六氯苯和林丹在经二乙基亚硝胺（DENA）预处理的大鼠中增强γ-谷氨酰转肽酶（GGTase）阳性灶发生率的能力。在接受DENA后再给予基础琼脂饮食的大鼠，或未预先给予DENA而直接给予六氯苯或林丹的大鼠中，GGTase阳性灶的发生率可忽略不计。当在饮食中给予六氯苯或林丹时，这些大鼠此前在给予DENA之前已接受了2/3部分肝切除术。结果表明，六氯苯和林丹的肝癌致癌性源于肿瘤促进作用。
