B淋巴细胞对三硝基苯基偶联的聚蔗糖的反应：对T淋巴细胞和Ia抗原阳性黏附细胞的需求
B-lymphocyte responses to trinitrophenyl-conjugated Ficoll: requirement for T lymphocytes and Ia-bearing adherent cells.
作者信息
Letvin N L, Benacerraf B, Germain R N
出版信息
Proc Natl Acad Sci U S A. 1981 Aug;78(8):5113-7. doi: 10.1073/pnas.78.8.5113.
These studies were done to characterize the cellular requirements for B-lymphocyte responses to the haptenated polysaccharide trinitrophenyl-conjugated Ficoll. By using an in vitro microculture system, it was demonstrated that hapten-specific anti-trinitrophenyl-conjugated Ficoll plaque-forming cell responses by B lymphocytes require Ia-bearing adherent accessory cells and Thy 1+ Lyt 1+2- nylon wool-nonadherent (T) lymphocytes. Such T cells could be primed in vivo with nonderivatized Ficoll to show carrier-specific helper cell function for derivatized Ficoll responses in vitro. The implications of these findings for our understanding of b-lymphocyte triggering by so-called T-independent antigens are discussed.
开展这些研究是为了明确B淋巴细胞对半抗原化多糖三硝基苯偶联菲可（trinitrophenyl-conjugated Ficoll）产生反应的细胞需求。通过使用体外微培养系统，证明B淋巴细胞对半抗原特异性的抗三硝基苯偶联菲可空斑形成细胞反应需要携带Ia抗原的黏附辅助细胞和Thy 1⁺Lyt 1⁺2⁻尼龙毛非黏附性（T）淋巴细胞。此类T细胞可在体内用未衍生化的菲可进行致敏，从而在体外对衍生化菲可反应表现出载体特异性辅助细胞功能。讨论了这些发现对于我们理解所谓的T细胞非依赖性抗原触发B淋巴细胞的意义。
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