T细胞系对抗原特异性产生免疫干扰素。
Antigen-specific production of immune interferon by T Cells lines.
作者信息
McKimm-Breschkin J L, Mottram P L, Thomas W R, Miller J F
出版信息
J Exp Med. 1982 Apr 1;155(4):1204-9. doi: 10.1084/jem.155.4.1204.
Abstract
Continuous cultures of T cells reactive to the hapten 4-ethoxymethylene-2-phenyloxazolone were tested for interferon production after antigenic stimulation in vitro. Induction of interferon was antigen-specific and also restricted by the I region of the major histocompatibility complex. Kinetics of antigen induced interferon production were different from those reported for mitogen induced synthesis.
摘要
对半抗原4-乙氧基亚甲基-2-苯基恶唑酮有反应的T细胞连续培养物，在体外经抗原刺激后检测其干扰素生成情况。干扰素的诱导具有抗原特异性，并且也受主要组织相容性复合体I区的限制。抗原诱导的干扰素生成动力学与有丝分裂原诱导合成所报道的动力学不同。
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