细胞毒性T淋巴细胞在对抗抗原或有丝分裂原时会产生免疫干扰素。
Cytotoxic T lymphocytes produce immune interferon in response to antigen or mitogen.
作者信息
Klein J R, Raulet D H, Pasternack M S, Bevan M J
出版信息
J Exp Med. 1982 Apr 1;155(4):1198-203. doi: 10.1084/jem.155.4.1198.
Abstract
Interferon (IFN) was found to be secreted by cloned lines of murine cytotoxic T lymphocytes in response to mitogenic or antigen specific stimulation. The IFN produced was shown to be of the immune type based on its sensitivity to pH 2.0 and on the ability of an antiserum to immune IFN to neutralize the antiviral activity.
摘要
研究发现，克隆的小鼠细胞毒性T淋巴细胞系在有丝分裂原或抗原特异性刺激下会分泌干扰素（IFN）。根据其对pH 2.0的敏感性以及抗免疫干扰素血清中和抗病毒活性的能力，所产生的干扰素被证明属于免疫型。
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本文引用的文献
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Antigen recognition by cloned cytotoxic T lymphocytes follows rules predicted by the altered-self hypothesis.克隆化细胞毒性T淋巴细胞的抗原识别遵循改变自身假说所预测的规则。
J Exp Med. 1982 Jan 1;155(1):111-25. doi: 10.1084/jem.155.1.111.
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Concanavalin A-inducible, interleukin-2-producing T cell hybridoma.伴刀豆球蛋白A诱导的、产生白细胞介素-2的T细胞杂交瘤
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Alloreactive cloned T cell lines. I. Interactions between cloned amplifier and cytolytic T cell lines.同种异体反应性克隆T细胞系。I. 克隆扩增性T细胞系与细胞溶解性T细胞系之间的相互作用。
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