Comparative serological studies with mammalian adenoviruses.

Nine serotypes of bovine adenovirus, five serotypes of ovine adenovirus, and four serotypes of porcine adenovirus were compared in reciprocal cross-neutralisation tests, to determine if viruses isolated from different species were indeed distinct serotypes. In addition, the above serotypes were tested for possible antigenic relationships with 28 of 32 human adenoviruses, by one-way cross neutralisation tests with human adenovirus antisera. The results indicated that all viruses tested were distinct serotypes. Ovine adenovirus types 4 and 5, until now not compared by neutralisation tests, were confirmed as separate serotypes.