卡介苗预处理对T细胞针对组织相容性抗原反应的抑制作用。
Suppression of T-cell responses to histocompatibility antigens by BCG pre-treatment.
作者信息
Orbach-Arbouys S, Castes M
出版信息
Immunology. 1980 Feb;39(2):263-8.
Abstract
The injection of 3 mg BCG into C57Bl/6 mice was followed 14 days later by a decrease in reactivity of spleen cells when engaged in mixed-lymphocyte reactions or in graft-versus-host reactions. In vitro, the lack of reactivity was due to an active suppression exerted mainly by the adherent population. In vivo, it was not possible to demonstrate active suppression.
摘要
给C57Bl/6小鼠注射3毫克卡介苗后14天，当脾细胞参与混合淋巴细胞反应或移植物抗宿主反应时，其反应性降低。在体外，反应性缺乏是由于主要由黏附细胞群体施加的主动抑制作用。在体内，无法证明存在主动抑制作用。
相似文献
1
Suppression of T-cell responses to histocompatibility antigens by BCG pre-treatment.
Immunology. 1980 Feb;39(2):263-8.
2
3
Age-related changes, including synergy and suppression, in the mixed lymphocyte reaction in long-lived mice.
Fed Proc. 1975 Feb;34(2):159-61.
4
5
Suppression of the mixed leukocyte response and of graft-vs-host disease by spleen cells following total lymphoid irradiation (TLI).
J Immunol. 1981 Mar;126(3):1140-5.
6
7
8
Active suppression masks an underlying enhancement of antibody production in vitro by spleen cells from BCG-infected mice.
Immunology. 1980 Jul;40(3):303-9.
9
引用本文的文献
1
Possible role of macrophage-like suppressor cells in the anti-tumour activity of BCG.
Br J Cancer. 1981 Dec;44(6):828-37. doi: 10.1038/bjc.1981.281.
本文引用的文献
1
2
A rapid method for the isolation of functional thymus-derived murine lymphocytes.
Eur J Immunol. 1973 Oct;3(10):645-9. doi: 10.1002/eji.1830031011.
3
Effect of allogeneic cell interaction on the primary immune response in vitro. Cell types involved in suppression and stimulation of antibody synthesis.
Clin Exp Immunol. 1972 Nov;12(3):365-75.
4
The response of T cells to histocompatibility-2 antigens. Dose-response kinetics.
J Exp Med. 1972 Jul 1;136(1):112-27. doi: 10.1084/jem.136.1.112.
5
Antigenic competition between heterologous erythrocytes. I. Thymic dependency.
J Immunol. 1971 Jun;106(6):1524-31.
6
Studies on antigenic competition. Efforts to identify the cellular basis of competition using a cell transfer system.
Cell Immunol. 1974 Jul;13(1):66-75. doi: 10.1016/0008-8749(74)90227-5.
7
On the mode of action of BCG.
Nat New Biol. 1973 Jun 13;243(128):216-8. doi: 10.1038/newbio243216a0.
8
Defect of macrophage function in the antibody response to sheep erythrocytes in systemic Mycobacterium lepraemurium infection.
Nature. 1975 Jul 17;256(5514):206-8. doi: 10.1038/256206b0.
9
10
Immunosuppression effected by macrophage surfaces.
J Immunol. 1975 Nov;115(5):1346-50.
Zotero 插件