Troost B T, Daroff R B
Ann Neurol. 1977 Nov;2(5):397-403. doi: 10.1002/ana.410020509.
The results of quantitative infrared horizontal eye movement recordings in 8 patients with progressive supranuclear palsy are presented. Some of the patients had total paralysis of vertical movements, but none had completely lost the ability to perform horizontal eye movements. All patients had a defect in ocular fixation previously undescribed in this condition: the universal presence of square-wave jerks. Analysis of refixation saccades demonstrated hypometria, slow velocity/amplitude relationships, and profound prolongation of duration. The pursuit abnormality, characterized clinically by "cogwheel" eye movements, represented the inability to match eye velocity to target velocity. The ratio of peak eye velocity to peak target velocity (pursuit gain) was 0.2 to 0.5. Defects in the vestibuloocular reflex included inability to increase the gain of the reflex (ratio of peak eye velocity to head velocity) during viewing of a visible, stationary target and failure to suppress the reflex when viewing a target rotating with the head.
本文呈现了8例进行性核上性麻痹患者定量红外水平眼动记录的结果。部分患者存在垂直运动完全麻痹，但无一例完全丧失水平眼动能力。所有患者均存在一种此前未在该疾病中描述过的眼球注视缺陷：普遍存在方波急跳。对重新注视扫视的分析显示扫视幅度减小、速度/幅度关系异常以及持续时间显著延长。追踪异常在临床上表现为“齿轮样”眼动，表现为无法使眼球速度与目标速度匹配。眼球峰值速度与目标峰值速度之比（追踪增益）为0.2至0.5。前庭眼反射缺陷包括在注视可见静止目标时无法增加反射增益（眼球峰值速度与头部速度之比），以及在注视随头部旋转的目标时无法抑制反射。
