Maillet P, Baulieux J, Boulez J, Benhaim R
Am J Surg. 1982 May;143(5):629-34. doi: 10.1016/0002-9610(82)90181-7.
A group of 271 squamous carcinomas of the thoracic esophagus were studied. All of these patients underwent the same operation: one-stage esophagogastrectomy through a combined abdominal and right thoracic approach. Adenocarcinomas, tumors of the cardia and excisions through a left-sided thoracic approach were excluded. The resectability of these tumors has increased progressively and, at present, applies to 74 percent of operative cases. A majority of these excisons (73 percent) were only palliative. Operative mortality was 16.6 percent for the group as a whole. In the last 3 years this rate has fallen to 4.6 percent. Overall survival at 5 years was 9.3 percent (8.7 percent without recurrence). There was a marked difference between the 5 year survival rate after curative excision (28 percent) and after palliative excision (2.3 percent). Despite such poor results, palliative excision remains justified and offers the patient longer and more comfortable survival than any other type of treatment. Two-stage excision represents a longer, more complex and more grave procedure than one-stage esophagogastrectomy. The addition of postoperative radiotherapy with or without chemotherapy in the last 3 years had led to a marked improvement in survival.
对271例胸段食管癌鳞状细胞癌患者进行了研究。所有这些患者均接受了相同的手术:经腹联合右胸入路一期食管胃切除术。腺癌、贲门肿瘤以及经左胸入路的切除术均被排除。这些肿瘤的可切除率逐渐提高,目前适用于74%的手术病例。这些切除术中的大多数(73%)仅为姑息性切除。整个组的手术死亡率为16.6%。在过去3年中,这一比率已降至4.6%。5年总生存率为9.3%(无复发率为8.7%)。根治性切除术后的5年生存率(28%)与姑息性切除术后的5年生存率(2.3%)之间存在显著差异。尽管结果不佳,但姑息性切除仍然合理,并且比任何其他类型的治疗方法能为患者提供更长、更舒适的生存期。两阶段切除比一期食管胃切除术更长、更复杂且更严重。在过去3年中,术后加用或不加用化疗的放疗已使生存率有了显著提高。