副粘病毒膜蛋白增强小鼠对肌动蛋白的抗体反应。

Paramyxovirus membrane protein augments the antibody response to actin in mice.

作者信息

Anomasiri W T, Tyrrell D L

机构信息

Department of Biochemistry, University of Alberta, Edmonton, Canada.

出版信息

Clin Exp Immunol. 1988 Oct;74(1):59-62.

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1541716/

Abstract

The production of anti-actin antibodies has been studied in mice. Not one of 10 mice immunized with native actin produced anti-actin antibodies, whereas seven out of 10 mice immunized with actin mixed with paramyxovirus membrane (M) protein produced a high titre of antibodies to actin. The enhancement of anti-actin antibody production by M protein is specific to actin since antibodies to protein purified derivatives (PPD) or gelatin were not enhanced by M protein. The enhanced anti-actin antibodies depended upon the interaction of actin and M protein since injection of M protein and actin in separate sites failed to produce anti-actin antibodies. Five Balb/c nude mice immunized with actin and M protein failed to produce anti-actin antibodies suggesting that cell-mediated immune response is also required for this response.

摘要

已在小鼠中研究了抗肌动蛋白抗体的产生。用天然肌动蛋白免疫的10只小鼠中没有一只产生抗肌动蛋白抗体，而用与副粘病毒膜（M）蛋白混合的肌动蛋白免疫的10只小鼠中有7只产生了高滴度的抗肌动蛋白抗体。M蛋白对抗肌动蛋白抗体产生的增强作用对肌动蛋白具有特异性，因为M蛋白不会增强针对蛋白质纯化衍生物（PPD）或明胶的抗体。增强的抗肌动蛋白抗体依赖于肌动蛋白和M蛋白的相互作用，因为在不同部位分别注射M蛋白和肌动蛋白未能产生抗肌动蛋白抗体。用肌动蛋白和M蛋白免疫的5只Balb/c裸鼠未能产生抗肌动蛋白抗体，这表明这种反应也需要细胞介导的免疫反应。

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本文引用的文献

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Molecular mimicry in virus infection: crossreaction of measles virus phosphoprotein or of herpes simplex virus protein with human intermediate filaments.病毒感染中的分子模拟：麻疹病毒磷蛋白或单纯疱疹病毒蛋白与人中间丝的交叉反应

Proc Natl Acad Sci U S A. 1983 Apr;80(8):2346-50. doi: 10.1073/pnas.80.8.2346.

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Evidence for an interaction between the membrane protein of a paramyxovirus and actin.副粘病毒膜蛋白与肌动蛋白之间相互作用的证据。

J Virol. 1982 Jun;42(3):963-8. doi: 10.1128/JVI.42.3.963-968.1982.

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J Immunol. 1982 Aug;129(2):683-8.

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Identification of a hemagglutinin-specific idiotype associated with reovirus recognition shared by lymphoid and neural cells.鉴定一种与呼肠孤病毒识别相关的血凝素特异性独特型，其为淋巴细胞和神经细胞所共有。

J Exp Med. 1982 Jan 1;155(1):155-67. doi: 10.1084/jem.155.1.155.

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