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Diverse mechanisms in the generation of human beta-tubulin pseudogenes.

作者信息

Wilde C D, Crowther C E, Cowan N J

出版信息

Science. 1982 Aug 6;217(4559):549. doi: 10.1126/science.6178164.

DOI:10.1126/science.6178164
PMID:6178164
Abstract

The sequence of two human beta-tubulin pseudogenes is described. One contains an intervening sequence but lacks sequences encoding the 55 N-terminal amino acids of the polypeptide chain. A second has no introns but has a polyadenylate signal and an oligoadenylate tract at its 3' end, and it is flanked by a short direct repeat. These sequences have arisen by different mechanisms, including one that probably involves reverse transcription of a processed messenger RNA and reintegration of the complementary DNA copy into the genome.

摘要

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