• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

一个由缺乏内含子和含有内含子的基因组成的多基因家族，编码小鼠核糖体蛋白L7。

A multigene family of intron lacking and containing genes, encoding for mouse ribosomal protein L7.

作者信息

Klein A, Meyuhas O

出版信息

Nucleic Acids Res. 1984 May 11;12(9):3763-76. doi: 10.1093/nar/12.9.3763.

DOI:10.1093/nar/12.9.3763
PMID:6328436
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC318788/
Abstract

Mouse ribosomal protein L7 is encoded by a multigene family. Screening of two mouse genomic libraries with cloned L7 cDNA, has resulted in the isolation of nine independent lambda Charon 4A recombinant phages which include seven different L7 genes. Restriction enzyme mapping of six of these genes (L7-1, L7-16, L7-18, L7-28, L7-35 and L7- 16b ) reveals dissimilarity in sites within the L7 sequences as well as in the flanking regions. Electron microscopic analysis of heteroduplex and S1 nuclease mapping demonstrate that the first five genes contain the entire L7 mRNA sequence but lack introns. Based on these features we propose that these are processed genes. Of the L7 genes described here only one (L7- 16b ) exhibits a high degree of homology with L7 mRNA and contains introns. We discuss the possibility that this low representation of intron containing L7 genes may reflect the proportion of functional L7 genes in this multigene family.

摘要

小鼠核糖体蛋白L7由一个多基因家族编码。用克隆的L7 cDNA筛选两个小鼠基因组文库，已分离出9个独立的λ噬菌体Charon 4A重组噬菌体，其中包括7个不同的L7基因。对其中6个基因（L7-1、L7-16、L7-18、L7-28、L7-35和L7-16b）进行限制性酶切图谱分析，结果显示L7序列内以及侧翼区域的位点存在差异。对异源双链体的电子显微镜分析和S1核酸酶图谱分析表明，前5个基因包含完整的L7 mRNA序列，但没有内含子。基于这些特征，我们认为这些是已加工基因。在这里描述的L7基因中，只有一个（L7-16b）与L7 mRNA具有高度同源性且含有内含子。我们讨论了含内含子的L7基因这种低比例情况可能反映该多基因家族中功能性L7基因比例的可能性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6729/318788/60fffcfec4fd/nar00327-0061-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6729/318788/594561831b79/nar00327-0056-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6729/318788/009b7a3205a4/nar00327-0057-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6729/318788/86893b2c90c4/nar00327-0058-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6729/318788/4bf5e9c421b9/nar00327-0059-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6729/318788/60fffcfec4fd/nar00327-0061-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6729/318788/594561831b79/nar00327-0056-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6729/318788/009b7a3205a4/nar00327-0057-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6729/318788/86893b2c90c4/nar00327-0058-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6729/318788/4bf5e9c421b9/nar00327-0059-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6729/318788/60fffcfec4fd/nar00327-0061-a.jpg

相似文献

1
A multigene family of intron lacking and containing genes, encoding for mouse ribosomal protein L7.一个由缺乏内含子和含有内含子的基因组成的多基因家族，编码小鼠核糖体蛋白L7。
Nucleic Acids Res. 1984 May 11;12(9):3763-76. doi: 10.1093/nar/12.9.3763.
2
Isolation and characterization of four mouse ribosomal-protein-L18 genes that appear to be processed pseudogenes.四个看似是加工假基因的小鼠核糖体蛋白-L18基因的分离与鉴定。
Gene. 1984 Jul-Aug;29(1-2):157-66. doi: 10.1016/0378-1119(84)90176-8.
3
The mammalian genome contains a high proportion of processed pseudogenes corresponding to ribosomal protein L19.哺乳动物基因组中含有高比例的与核糖体蛋白L19相对应的加工假基因。
Biochem Int. 1990 Dec;22(5):921-8.
4
Structural and functional properties of ribosomal protein L7 from humans and rodents.人类和啮齿动物核糖体蛋白L7的结构与功能特性
Nucleic Acids Res. 1993 Jan 25;21(2):223-31. doi: 10.1093/nar/21.2.223.
5
Human L7a ribosomal protein: sequence, structural organization, and expression of a functional gene.人L7a核糖体蛋白：功能基因的序列、结构组织及表达
Gene. 1993 Apr 30;126(2):227-35. doi: 10.1016/0378-1119(93)90371-9.
6
Characterization of the multigene family encoding the mouse S16 ribosomal protein: strategy for distinguishing an expressed gene from its processed pseudogene counterparts by an analysis of total genomic DNA.编码小鼠S16核糖体蛋白的多基因家族的特征分析：通过对总基因组DNA的分析来区分一个表达基因与其加工假基因对应物的策略。
Mol Cell Biol. 1985 Dec;5(12):3560-76. doi: 10.1128/mcb.5.12.3560-3576.1985.
7
Variation between mouse major urinary protein genes isolated from a single inbred line.从单一近交系小鼠中分离出的主要尿蛋白基因之间的差异。
Gene. 1982 Jun;18(3):221-30. doi: 10.1016/0378-1119(82)90159-7.
8
Molecular characterization of the mouse ribosomal protein S24 multigene family: a uniquely expressed intron-containing gene with cell-specific expression of three alternatively spliced mRNAs.小鼠核糖体蛋白S24多基因家族的分子特征：一个独特表达的含内含子基因，其三种可变剪接mRNA具有细胞特异性表达。
Nucleic Acids Res. 1994 Feb 25;22(4):646-55. doi: 10.1093/nar/22.4.646.
9
Hamster ribosomal protein S24 multigene family: genomic organization and molecular structure of two pseudogenes.仓鼠核糖体蛋白S24多基因家族：两个假基因的基因组结构和分子结构
Biochem Cell Biol. 1997;75(2):177-82.
10
P31, a mammalian housekeeping protein encoded by a multigene family containing a high proportion of pseudogenes.P31是一种哺乳动物管家蛋白，由一个包含高比例假基因的多基因家族编码。
Biochim Biophys Acta. 1985 Nov 13;826(2-3):137-46. doi: 10.1016/0167-4781(85)90119-8.

引用本文的文献

1
Structural and functional properties of ribosomal protein L7 from humans and rodents.人类和啮齿动物核糖体蛋白L7的结构与功能特性
Nucleic Acids Res. 1993 Jan 25;21(2):223-31. doi: 10.1093/nar/21.2.223.
2
Molecular characterization of the mouse ribosomal protein S24 multigene family: a uniquely expressed intron-containing gene with cell-specific expression of three alternatively spliced mRNAs.小鼠核糖体蛋白S24多基因家族的分子特征：一个独特表达的含内含子基因，其三种可变剪接mRNA具有细胞特异性表达。
Nucleic Acids Res. 1994 Feb 25;22(4):646-55. doi: 10.1093/nar/22.4.646.
3
Identification and genetic mapping of 151 dispersed members of 16 ribosomal protein multigene families in the mouse.

本文引用的文献

1
Chromosomal distribution of ribosomal protein genes in the mouse.核糖体蛋白基因在小鼠中的染色体分布。
Cell. 1981 May;24(2):307-12. doi: 10.1016/0092-8674(81)90320-2.
2
Mammals have multiple genes for individual ribosomal proteins.哺乳动物的单个核糖体蛋白有多个基因。
Cell. 1981 May;24(2):301-6. doi: 10.1016/0092-8674(81)90319-6.
3
Human metallothionein genes--primary structure of the metallothionein-II gene and a related processed gene.人类金属硫蛋白基因——金属硫蛋白-II基因及一个相关加工基因的一级结构
小鼠中16个核糖体蛋白多基因家族的151个分散成员的鉴定与基因定位。
Mamm Genome. 1994 Nov;5(11):670-87. doi: 10.1007/BF00426073.
4
Characterization of the expressed gene and several processed pseudogenes for the mouse ribosomal protein L30 gene family.小鼠核糖体蛋白L30基因家族的表达基因及几个加工假基因的特征分析。
Mol Cell Biol. 1984 Nov;4(11):2518-28. doi: 10.1128/mcb.4.11.2518-2528.1984.
5
Characterization of the multigene family encoding the mouse S16 ribosomal protein: strategy for distinguishing an expressed gene from its processed pseudogene counterparts by an analysis of total genomic DNA.编码小鼠S16核糖体蛋白的多基因家族的特征分析：通过对总基因组DNA的分析来区分一个表达基因与其加工假基因对应物的策略。
Mol Cell Biol. 1985 Dec;5(12):3560-76. doi: 10.1128/mcb.5.12.3560-3576.1985.
6
A processed pseudogene in an intron of the HLA-DP beta 1 chain gene is a member of the ribosomal protein L32 gene family.HLA-DPβ1链基因内含子中的一个加工假基因是核糖体蛋白L32基因家族的成员。
Nucleic Acids Res. 1985 Dec 20;13(24):8883-91. doi: 10.1093/nar/13.24.8883.
7
Primary structure of human ribosomal protein S14 and the gene that encodes it.人类核糖体蛋白S14的一级结构及其编码基因。
Mol Cell Biol. 1986 Aug;6(8):2774-83. doi: 10.1128/mcb.6.8.2774-2783.1986.
8
The primary structure of rat ribosomal protein S8.大鼠核糖体蛋白S8的一级结构。
Nucleic Acids Res. 1987 Nov 25;15(22):9451-9. doi: 10.1093/nar/15.22.9451.
9
Homologous ribosomal proteins in bacteria, yeast, and humans.细菌、酵母和人类中的同源核糖体蛋白。
Proc Natl Acad Sci U S A. 1986 Sep;83(18):6907-11. doi: 10.1073/pnas.83.18.6907.
10
Primary structure of the ribosomal protein gene S6 from Schizosaccharomyces pombe.粟酒裂殖酵母核糖体蛋白基因S6的一级结构
Curr Genet. 1988;13(1):57-63. doi: 10.1007/BF00365757.
Nature. 1982 Oct 28;299(5886):797-802. doi: 10.1038/299797a0.
4
The effect of temperature-sensitive RNA mutants on the transcription products from cloned ribosomal protein genes of yeast.温度敏感型RNA突变体对酵母核糖体蛋白基因克隆转录产物的影响。
Cell. 1981 Jun;24(3):679-86. doi: 10.1016/0092-8674(81)90094-5.
5
Construction and identification of cDNA clones for mouse ribosomal proteins: application for the study of r-protein gene expression.小鼠核糖体蛋白cDNA克隆的构建与鉴定：在核糖体蛋白基因表达研究中的应用
Gene. 1980 Jul;10(2):113-29. doi: 10.1016/0378-1119(80)90129-8.
6
Unusual alpha-globin-like gene that has cleanly lost both globin intervening sequences.异常的类α珠蛋白基因，其已完全缺失两个珠蛋白内含子序列。
Proc Natl Acad Sci U S A. 1980 May;77(5):2806-9. doi: 10.1073/pnas.77.5.2806.
7
The sequences of an expressed rat alpha-tubulin gene and a pseudogene with an inserted repetitive element.一个表达的大鼠α-微管蛋白基因和一个插入重复元件的假基因的序列。
Nature. 1982 Nov 25;300(5890):330-5. doi: 10.1038/300330a0.
8
Processed genes: a dispersed human immunoglobulin gene bearing evidence of RNA-type processing.加工后的基因：一个带有RNA类型加工证据的分散人类免疫球蛋白基因。
Nature. 1982 Mar 25;296(5855):321-5. doi: 10.1038/296321a0.
9
Tissue-specific expression of a chicken calmodulin pseudogene lacking intervening sequences.缺乏间隔序列的鸡钙调蛋白假基因的组织特异性表达。
Proc Natl Acad Sci U S A. 1983 Nov;80(21):6485-9. doi: 10.1073/pnas.80.21.6485.
10
Cycloheximide resistance in yeast: the gene and its protein.酵母中的环己酰亚胺抗性：基因及其蛋白
Nucleic Acids Res. 1983 May 25;11(10):3123-35. doi: 10.1093/nar/11.10.3123.