Saraux B, Girard-Globa A, Ouagued M, Vacher D
Am J Physiol. 1982 Jul;243(1):G10-5. doi: 10.1152/ajpgi.1982.243.1.G10.
In the rat, pancreatic amylase and, to a lesser extent, lipase adapt quantitatively to the amount of their respective substrates in the diet by an increase in specific activity and total contents (range of variation, fivefold for amylase and twofold for lipase). Colipase responded to protein intake (r = 0.85, P less than 0.01) and not to lipids provided protein intake was below 3.5 g or above 6.0 g. With this latter amount of protein, a maximal level was obtained, even with 2% lipid in the diet. Between 3.5 and 6.0 g, lipid intake was found to modulate colipase in parallel with lipase. When different types of fat were compared, the degree of saturation was found to have no impact on lipase, colipase, and amylase. Diets containing medium-chain triglycerides (C8-C10) did not maximally increase specific activity and total content of lipase and colipase, whereas they did not repress amylase as much longer chain triglycerides did. With coconut oil (45% C12), lipase was maximally stimulated but amylase was not maximally repressed, showing that the regulation of the hydrolases may be partly reciprocal and partly independent.
在大鼠中，胰腺淀粉酶以及在较小程度上的脂肪酶，通过比活性和总量的增加（变化范围：淀粉酶为五倍，脂肪酶为两倍），在数量上适应饮食中各自底物的量。辅脂酶对蛋白质摄入量有反应（r = 0.85，P < 0.01），如果蛋白质摄入量低于3.5克或高于6.0克，则对脂质无反应。当蛋白质摄入量为后者时，即使饮食中脂质含量为2%，也能达到最高水平。在3.5至6.0克之间，发现脂质摄入量与脂肪酶平行调节辅脂酶。当比较不同类型的脂肪时，发现饱和度对脂肪酶、辅脂酶和淀粉酶没有影响。含有中链甘油三酯（C8 - C10）的饮食并没有最大程度地增加脂肪酶和辅脂酶的比活性和总量，而它们对淀粉酶的抑制作用不如长链甘油三酯那么大。对于椰子油（45% C12），脂肪酶受到最大刺激，但淀粉酶没有受到最大抑制，这表明水解酶的调节可能部分是相互的，部分是独立的。
