LaSure M M, Perez-Jimenez F, Singh M
Dig Dis Sci. 1986 Oct;31(10):1073-80. doi: 10.1007/BF01300260.
The present study was done to determine the effect of the interaction of ethanol and an average or high-fat diet on pancreatic acinar cell function. Weight-matched groups of Sprague-Dawley rats were fed regular rat feed or average fat and high-fat liquid diets with or without 5% (w/v) concentration of ethanol for 3 months. Trypsinogen secretion was increased by the high-fat diet but not by ethanol; chymotrypsinogen secretion was decreased by the combination of ethanol and a high-fat diet, while lipase secretion was increased by a high-fat diet. Pancreatic secretory trypsin inhibitor was not significantly altered by ethanol or fat in the diet. Ethanol feeding together with a high-fat content of the diet caused complex and nonparallel changes in the secretion of the pancreatic enzymes. These data are of interest in view of the reported positive correlation between alcoholism and a high-fat content of the diet in the causation of alcoholic pancreatitis in humans.
本研究旨在确定乙醇与普通或高脂饮食的相互作用对胰腺腺泡细胞功能的影响。将体重匹配的斯普拉格-道利大鼠分组，分别给予常规大鼠饲料、普通脂肪和高脂液体饮食，添加或不添加5%（w/v）浓度的乙醇，持续3个月。高脂饮食可增加胰蛋白酶原分泌，但乙醇无此作用；乙醇与高脂饮食联合可降低糜蛋白酶原分泌，而高脂饮食可增加脂肪酶分泌。饮食中的乙醇或脂肪对胰腺分泌性胰蛋白酶抑制剂无显著影响。乙醇与高脂饮食共同喂养导致胰腺酶分泌发生复杂且不平行的变化。鉴于在人类酒精性胰腺炎病因中，酗酒与高脂饮食之间存在报道的正相关，这些数据很有意思。
