Grendell J H, Rothman S S
Am J Physiol. 1982 Jul;243(1):G54-9. doi: 10.1152/ajpgi.1982.243.1.G54.
The relation between plasma and biliary amylase activity and their relationship to the functional state of the pancreas were studied in anesthetized rabbits. Repetitive intravenous injections of cholecystokinin resulted in a 25-fold rise in the secretion of amylase via the pancreatic duct, followed at first by a 50% increase in plasma amylase concentration and later by a 270% increase in biliary amylase concentration. There was then a gradual, roughly synchronous decline in both plasma and biliary values toward basal level despite a continued highly augmented rate of pancreatic ductal secretion. "Near-total" pancreatectomy completely abolished the effect. These observations are consistent with a cholecystokinin-induced basolateral secretion of amylase from pancreas into blood and its subsequent movement from blood into bile down a concentration gradient. The output of amylase in bile, however, was quite small and does not suggest that biliary transport of amylase has an important function either as a means of secreting and recycling digestive enzyme into the gut or as a major excretory pathway for circulating amylase in the rabbit.
在麻醉兔身上研究了血浆和胆汁淀粉酶活性之间的关系及其与胰腺功能状态的关系。重复静脉注射胆囊收缩素导致通过胰管分泌的淀粉酶增加25倍，随后血浆淀粉酶浓度首先增加50%，随后胆汁淀粉酶浓度增加270%。尽管胰管分泌率持续大幅增加，但血浆和胆汁值随后逐渐大致同步下降至基础水平。“近全”胰腺切除术完全消除了这种效应。这些观察结果与胆囊收缩素诱导淀粉酶从胰腺基底外侧分泌到血液中，随后从血液中沿浓度梯度进入胆汁的现象一致。然而，胆汁中淀粉酶的输出量相当小，这并不表明胆汁中淀粉酶的转运作为将消化酶分泌和再循环到肠道的一种方式，或作为兔体内循环淀粉酶的主要排泄途径具有重要功能。
