Steer M L, Glazer G
Am J Physiol. 1976 Dec;231(6):1860-5. doi: 10.1152/ajplegacy.1976.231.6.1860.
Nonparallel discharge of digestive enzymes by the in vitro rabbit pancreas has been previously reported and this observation has been used to challenge the mass transport theory of enzyme synthesis and secretion by the exocrine pancreas. The current investigation reexamines the pattern of enzyme secretion from the in vitro rabbit pancreas. Secretion of alpha-amylase, trypsinogen, and chymotrypsinogen was studied from the unstimulated gland and from glands stimulated with either methacholine, cholecystokinin-pancreozymin, or the active octapeptide of cholecystokinin-pancreozymin. In all cases, only parallel discharge of alpha-amlyse, trypsinogen, and chymotrypsinogen was noted. These observations are consistent with the mass-transport theory.
先前已有报道称，体外培养的兔胰腺存在消化酶的非平行分泌现象，这一观察结果被用于质疑外分泌胰腺酶合成与分泌的质量传输理论。当前的研究重新审视了体外培养的兔胰腺的酶分泌模式。研究了未受刺激的腺体以及用乙酰甲胆碱、胆囊收缩素-促胰酶素或胆囊收缩素-促胰酶素的活性八肽刺激后的腺体中α-淀粉酶、胰蛋白酶原和糜蛋白酶原的分泌情况。在所有情况下，均仅观察到α-淀粉酶、胰蛋白酶原和糜蛋白酶原的平行分泌。这些观察结果与质量传输理论相符。
