Barrett A, Jacobs A, Kohn J, Raymond J, Powles R L
Br Med J (Clin Res Ed). 1982 Jul 17;285(6336):170-1. doi: 10.1136/bmj.285.6336.170.
A study was carried out to assess the effect of total body irradiation on pancreatic and parotid isoenzymes of amylase in patients about to undergo bone-marrow transplantation who had received high-dose cyclophosphamide. Twelve patients were studied, enzyme activity being measured before and at various times after total body irradiation. Serum total amylase activity rose rapidly within 12 hours of irradiation to a maximum at 36 hours, returning to normal by six days; most of the increase was derived from salivary damage, with a much smaller pancreatic component. These results confirm that radiation produces acute changes in amylase activity, which may be of use in assessing radiation-induced damage.
一项研究旨在评估全身照射对即将接受骨髓移植且已接受高剂量环磷酰胺治疗的患者胰腺和腮腺淀粉酶同工酶的影响。研究了12名患者，在全身照射前及照射后的不同时间测量酶活性。血清总淀粉酶活性在照射后12小时内迅速上升，在36小时达到峰值，6天后恢复正常；大部分升高源于唾液腺损伤，胰腺成分所占比例小得多。这些结果证实，辐射会使淀粉酶活性产生急性变化，这可能有助于评估辐射诱导的损伤。
