Rak G, Anke H
J Antibiot (Tokyo). 1982 Apr;35(4):436-40. doi: 10.7164/antibiotics.35.436.
8006-I is an antibacterial antibiotic with a rather broad spectrum of activity. The minimum inhibitory concentrations for the most sensitive bacteria are in the range of one to ten micrograms/ml. Yeasts are not affected by concentrations up to 100 micrograms/ml. Some filamentous fungi like Fusarium oxysporum and Mucor miehei are inhibited at 100 micrograms/ml. In Ehrlich carcinoma ascitic cells the incorporation of uridine and leucine and to a lesser extent that of thymidine is reduced. In isolated nuclei of these cells the incorporation of UTP into RNA is inhibited. At low concentrations, the incorporation of uracil into trichloroacetic acid-precipitable material is almost completely inhibited in cells of Bacillus subtilis; at higher concentrations all macromolecular syntheses are affected. No reduction of respiration of the cells is observed. The antibiotic exhibits weak hemolytic activity and lytic activity towards bacteria. In vitro an inhibition of both DNA- and RNA polymerase from Escherichia coli is observed. Poly(U)-directed poly(Phe) synthesis is not affected.
8006 - I是一种抗菌抗生素，具有相当广泛的活性谱。对最敏感细菌的最低抑菌浓度在1至10微克/毫升范围内。酵母在浓度高达100微克/毫升时不受影响。一些丝状真菌，如尖孢镰刀菌和米黑毛霉，在100微克/毫升时受到抑制。在艾氏癌腹水细胞中，尿苷和亮氨酸的掺入以及胸腺嘧啶核苷的掺入在较小程度上减少。在这些细胞的分离核中，UTP掺入RNA受到抑制。在低浓度下，枯草芽孢杆菌细胞中尿嘧啶掺入三氯乙酸可沉淀物质的过程几乎完全受到抑制；在较高浓度下，所有大分子合成均受到影响。未观察到细胞呼吸的降低。该抗生素对细胞表现出较弱的溶血活性和对细菌的裂解活性。在体外观察到对大肠杆菌的DNA和RNA聚合酶均有抑制作用。聚（U）指导的聚（Phe）合成不受影响。
