Chihara E, Sakugawa M, Entani S
Brain Res. 1982 Jun 3;241(1):179-81. doi: 10.1016/0006-8993(82)91243-4.
Orthograde fast axonal transport was almost completely blocked one day after the intraocular injection of 10-100 micrograms of vinblastine (VLB), then recovered gradually for up to 2 months. Recovery was not complete, however; there was a definite relationship between the dose of VLB administered and the degree of recovery of fast axonal transport. Retinal protein synthesis was reduced by intraocular VLB, but there was no relationship between the dose administered and the amount of reduction of protein synthesis. Cytotoxicity of VLB to the retina is less probable. The participation of retrograde axonal transport in the metabolism of cell bodies is discussed.
眼内注射10 - 100微克长春碱（VLB）一天后，顺行性快速轴突运输几乎完全被阻断，然后逐渐恢复长达2个月。然而，恢复并不完全；所给予的VLB剂量与快速轴突运输的恢复程度之间存在明确的关系。眼内注射VLB可使视网膜蛋白质合成减少，但所给予的剂量与蛋白质合成减少量之间没有关系。VLB对视网膜的细胞毒性可能性较小。本文讨论了逆行轴突运输在细胞体代谢中的作用。
