Chihara E, Sakugawa M, Entani S
Brain Res. 1982 Nov 4;250(2):363-6. doi: 10.1016/0006-8993(82)90432-2.
Protein synthesis in the retina in diabetic rabbits decreased as the severity of the diabetes increased, but protein degradation and replacement were not affected. The reduction in the amount of orthograde slow axonal transport in diabetic rabbits closely paralleled the reduction in the amount of fast axonal transport and protein synthesis in the retina. The reduction in slow flow is most probably a simple reflection of reduced protein synthesis in the retinal ganglion cells. The relationships among reduction in axon diameter, volume of perikaryon, slow axonal transport and diabetic neuropathy are discussed.
随着糖尿病严重程度的增加，糖尿病兔视网膜中的蛋白质合成减少，但蛋白质降解和更替不受影响。糖尿病兔顺向慢速轴突运输量的减少与视网膜中快速轴突运输量和蛋白质合成的减少密切平行。慢速运输的减少很可能只是视网膜神经节细胞中蛋白质合成减少的一种反映。文中讨论了轴突直径减小、胞体体积、慢速轴突运输和糖尿病性神经病变之间的关系。
