Chihara E
J Neurochem. 1981 Jul;37(1):247-50. doi: 10.1111/j.1471-4159.1981.tb05316.x.
Protein biosynthesis in the retina and fast axonal transport along the optic pathway were studied in rabbits in which diabetes had been experimentally induced. Retinal protein biosynthesis and axonal transport were significantly reduced in the diabetic rabbits, and the reduction was correlated to the severity of the diabetes. The "somal delay time' was only slightly elongated and the O/R ratio was fairly constant in the various levels of blood glucose; thus intrasomal protein movement seems to be less affected in diabetic rabbits. Velocity and the distribution pattern of axonally transported protein remained unaffected in the diabetic rabbits. These findings suggest that a disturbance in the metabolism in the cell body is the most important factor related to quantitative reduction of fast axonal transport in diabetic rabbits.
在实验性诱发糖尿病的兔子中，研究了视网膜中的蛋白质生物合成以及沿视神经通路的快速轴突运输。糖尿病兔子的视网膜蛋白质生物合成和轴突运输显著减少，且这种减少与糖尿病的严重程度相关。在不同血糖水平下，“胞体延迟时间”仅略有延长，O/R 比值相当恒定；因此，糖尿病兔子胞体内的蛋白质移动似乎受影响较小。糖尿病兔子中轴突运输蛋白质的速度和分布模式未受影响。这些发现表明，细胞体内代谢紊乱是与糖尿病兔子快速轴突运输定量减少相关的最重要因素。
