Johnson H M, Farrar W L, Torres B A
J Immunol. 1982 Sep;129(3):983-6.
The neuroendocrine antidiuretic hormone arginine vasopressin (AVP) was capable of replacing the interleukin 2 (IL 2) requirement for gamma-interferon (IFN gamma) production by Lyt-2+ cells from C57BL/6 mouse spleen cells. The AVP replacement did not stimulate DNA synthesis in the target lymphocytes. This suggested that AVP was capable of replacing an IL 2 function that did not involve stimulation of cellular proliferation or DNA synthesis. This was confirmed by the demonstration that mitomycin C inhibition of IFN gamma production was reversed by IL 2 or AVP without concomitant reversal of blockage of DNA synthesis. Oxytocin, which is structurally related to AVP, was also capable of replacing IL 2 requirement for IFN gamma production, whereas insulin was ineffective. The data show that the neuroendocrine hormones AVP and oxytocin are capable of lymphokine-like activity. This activity may involve the induction of a second messenger such as cyclic GMP.
神经内分泌抗利尿激素精氨酸加压素（AVP）能够替代白细胞介素2（IL - 2），满足C57BL / 6小鼠脾细胞中Lyt - 2 +细胞产生γ - 干扰素（IFNγ）的需求。AVP替代物不会刺激靶淋巴细胞中的DNA合成。这表明AVP能够替代一种不涉及刺激细胞增殖或DNA合成的IL - 2功能。这一点通过以下证明得到证实：丝裂霉素C对IFNγ产生的抑制作用可被IL - 2或AVP逆转，而DNA合成的阻断并未同时逆转。与AVP结构相关的催产素也能够替代IL - 2以满足IFNγ产生的需求，而胰岛素则无效。数据表明神经内分泌激素AVP和催产素具有类似淋巴因子的活性。这种活性可能涉及诱导第二信使如环鸟苷酸（cGMP）。
