Leventhal A G
J Neurosci. 1982 Aug;2(8):1024-42. doi: 10.1523/JNEUROSCI.02-08-01024.1982.
Electrophoretic injections of horseradish peroxidase were made into physiologically characterized sites within the different layers of the dorsal lateral geniculate nuclei (LGNd) of normal and Siamese cats. The histochemical procedures used stained the cell bodies, dendrites, and axons of retrogradely labeled ganglion cells. In both normal and Siamese cats, only alpha and beta ganglion cells are labeled by injections restricted to the A laminae. In normal cats, the alpha/beta ratios (number of labeled alpha cells/number of labeled alpha + beta cells) resulting from injections into lamina A increase from about 0.045 at 0.5 mm from the area centralis to about 0.12 in the far periphery. The alpha/beta ratios observed outside of the area centralis in normal cats following injections into different parts of lamina A1 were lower at each eccentricity than those resulting from injections into corresponding parts of lamina A. Also, the cell bodies and dendritic fields of alpha and beta cells projecting to lamina A1 are somewhat larger than those projecting to corresponding parts of lamina A. Outside of the area centralis, the relative numbers of alpha and beta cells projecting to Siamese lamina A are normal. However, alpha cells comprise an abnormally small proportion of ganglion cells projecting to the normal segments of Siamese lamina A1 and an abnormally large proportion of cells projecting to the abnormal segments of lamina A1. In Siamese cats, alpha and beta cells projecting to lamina A1 are distributed continuously throughout virtually all of the ipsilateral and contralateral temporal retinas. Since large parts of the ipsilateral and contralateral hemifields are not represented in Siamese lamina A1, it seems that some of the retinal afferents to this lamina are being suppressed. Injections into the C laminae of the LGNd show that the same morphological classes of ganglion cells project to these laminae in normal and Siamese cats. The classes projecting to the contralateral as C laminae (laminae C and C2) include alpha, beta, gamma, and epsilon as well as two other groups of cells referred to g1 and g2 cells, gamma, epsilon, g1, and g2 cells project to the ipsilateral C lamina (lamina C1). In siamese, but not in normal cats, examples of all of these types are found far into the contralateral temporal retina following injections involving lamina C1. This indicates that all classes projecting to the ipsilateral C lamina misproject in Siamese cats.
将辣根过氧化物酶电泳注入正常猫和暹罗猫背外侧膝状核（LGNd）不同层内生理特性明确的部位。所采用的组织化学方法对逆行标记的神经节细胞的胞体、树突和轴突进行了染色。在正常猫和暹罗猫中，仅局限于A层的注射标记了α和β神经节细胞。在正常猫中，向A层注射后得到的α/β比率（标记的α细胞数量/标记的α + β细胞数量）从距中央凹0.5毫米处的约0.045增加到远周边处的约0.12。正常猫在向A1层不同部位注射后，在中央凹以外观察到的α/β比率在每个偏心度下都低于向A层相应部位注射所得到的比率。此外，投射到A1层的α和β细胞的胞体和树突野比投射到A层相应部位的细胞稍大。在中央凹以外，投射到暹罗猫A层的α和β细胞的相对数量是正常的。然而，α细胞在投射到暹罗猫A1层正常节段的神经节细胞中所占比例异常小，而在投射到A1层异常节段的细胞中所占比例异常大。在暹罗猫中，投射到A1层的α和β细胞几乎连续分布于同侧和对侧颞侧视网膜的所有部位。由于暹罗猫的A1层没有代表同侧和对侧大部分半视野，似乎该层的一些视网膜传入纤维受到了抑制。向LGNd的C层注射显示，正常猫和暹罗猫中投射到这些层的神经节细胞形态类别相同。投射到对侧C层（C层和C2层）的类别包括α、β、γ和ε以及另外两组细胞，称为g1和g2细胞，γ、ε、g1和g2细胞投射到同侧C层（C1层）。在暹罗猫而非正常猫中，在涉及C1层的注射后，在对侧颞侧视网膜深处发现了所有这些类型的例子。这表明在暹罗猫中，所有投射到同侧C层的类别都发生了错误投射。
