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1
T-cell proliferative response to hapten-modified self-immunoglobulins: recognition of conjugate-specific determinants.T细胞对半抗原修饰的自身免疫球蛋白的增殖反应：共轭特异性决定簇的识别
Proc Natl Acad Sci U S A. 1982 Jul;79(13):4156-60. doi: 10.1073/pnas.79.13.4156.
2
Hapten-specific T cell responses to 4-hydroxy-3-nitrophenyl acetyl. XII. Fine specificity of anti-idiotypic suppressor T cells (Ts2).对半抗原4-羟基-3-硝基苯乙酰的特异性T细胞应答。十二、抗独特型抑制性T细胞（Ts2）的精细特异性
J Exp Med. 1981 Nov 1;154(5):1382-9. doi: 10.1084/jem.154.5.1382.
3
4-Hydroxy-3-nitrophenyl (NP) acetyl-hapten specific lymphocyte proliferation. I. Mice bearing Igh-1b allotype can cross-react with 4-hydroxy-5-iodo-3-nitrophenyl (NIP) acetyl hapten.4-羟基-3-硝基苯基（NP）乙酰半抗原特异性淋巴细胞增殖。I. 携带Igh-1b同种异型的小鼠可与4-羟基-5-碘-3-硝基苯基（NIP）乙酰半抗原发生交叉反应。
Microbiol Immunol. 1984;28(4):471-9. doi: 10.1111/j.1348-0421.1984.tb00698.x.
4
Influence of Igh-C- and MHC-linked genes on the activity of immunoglobulin-recognizing T cells.免疫球蛋白重链恒定区（Igh-C）基因和主要组织相容性复合体（MHC）相关基因对免疫球蛋白识别性T细胞活性的影响。
J Immunol. 1983 Jul;131(1):103-8.
5
Cell co-operation and hapten--carrier complexes.细胞合作与半抗原-载体复合物
Immunology. 1975 Oct;29(4):675-85.
6
Restriction fine specificity of long-term, hapten-specific cytotoxic T cell clones: analysis with H-2Kbm-mutant mice and H-2Kb-specific monoclonal antibodies.长期半抗原特异性细胞毒性T细胞克隆的限制性精细特异性：用H-2Kbm突变小鼠和H-2Kb特异性单克隆抗体进行分析。
Eur J Immunol. 1984 Feb;14(2):144-52. doi: 10.1002/eji.1830140208.
7
Cell-to-cell interaction controlled by immunoglobulin genes. Role of Thy-1-, Lyt-1+, Ig+ (B') cell in allotype-restricted antibody production.由免疫球蛋白基因控制的细胞间相互作用。Thy-1-、Lyt-1+、Ig+（B'）细胞在同种异型限制抗体产生中的作用。
J Exp Med. 1982 Aug 1;156(2):443-53. doi: 10.1084/jem.156.2.443.
8
The specificity of cellular immune responses II. The structure of antigenic determinants leading to T-lymphocyte stimulation.细胞免疫反应的特异性II. 导致T淋巴细胞刺激的抗原决定簇的结构
J Exp Med. 1976 Dec 1;144(6):1621-40. doi: 10.1084/jem.144.6.1621.
9
Clonal analysis of B and T cell responses to Ia antigens. IV. Proliferative T cell clones recognizing E beta and/or E alpha allodeterminants.B细胞和T细胞对Ia抗原反应的克隆分析。IV. 识别Eβ和/或Eα同种异体决定簇的增殖性T细胞克隆。
J Immunol. 1983 Mar;130(3):1262-7.
10
Hapten-specific helper T cells III. Fine specificity of the (4-hydroxy-3-nitro-phenyl)acetyl (NP)-specific response in Igh-1b mice.半抗原特异性辅助性T细胞III. Igh-1b小鼠中（4-羟基-3-硝基苯基）乙酰基（NP）特异性应答的精细特异性
Eur J Immunol. 1981 Mar;11(3):172-4. doi: 10.1002/eji.1830110303.

引用本文的文献

1
Tolerance for self IG at the level of the Ly1+ T cell.Ly1+ T细胞水平对自身免疫球蛋白的耐受性。
J Exp Med. 1983 Dec 1;158(6):1868-80. doi: 10.1084/jem.158.6.1868.

本文引用的文献

1
The carrier effect in the secondary response to hapten-protein conjugates. II. Cellular cooperation.对半抗原-蛋白质偶联物二次应答中的载体效应。II. 细胞协作。
Eur J Immunol. 1971 Jan;1(1):18-27. doi: 10.1002/eji.1830010104.
2
Induction of T and B cell immunity by anti-idiotypic antibody.抗独特型抗体诱导T细胞和B细胞免疫
Eur J Immunol. 1975 Oct;5(10):661-6. doi: 10.1002/eji.1830051002.
3
Idiotypy of clonal responses to influenza virus hemagglutinin.针对流感病毒血凝素的克隆反应的独特型
J Exp Med. 1981 Nov 1;154(5):1525-38. doi: 10.1084/jem.154.5.1525.
4
Functional helper activity of monoclonal T cell populations: antigen-specific and H-2 restricted cloned T cells provide help for in vitro antibody responses to trinitrophenyl-poly(LTyr,Glu)-poly(DLAla)--poly(LLys).单克隆T细胞群体的功能性辅助活性：抗原特异性且受H-2限制的克隆化T细胞为体外针对三硝基苯基-聚（L-酪氨酸，L-谷氨酸）-聚（D-丙氨酸）-聚（L-赖氨酸）的抗体应答提供辅助。
Proc Natl Acad Sci U S A. 1981 Oct;78(10):6431-5. doi: 10.1073/pnas.78.10.6431.
5
Balb/c T cells have the potential to recognize the TEPC 15 prototype antibody and its somatic variants.Balb/c T细胞有识别TEPC 15原型抗体及其体细胞变体的潜力。
J Exp Med. 1981 Oct 1;154(4):1178-87. doi: 10.1084/jem.154.4.1178.
6
Antigen-specific helper T cells required for dominant idiotype expression are not H-2 restricted.优势独特型表达所需的抗原特异性辅助性T细胞不受H-2限制。
J Exp Med. 1981 Aug 1;154(2):411-21. doi: 10.1084/jem.154.2.411.
7
Hapten-specific T cell responses to 4-hydroxy-3-nitrophenyl acetyl. VI. Evidence for different T cell receptors in cells that mediate H-21-restricted and H-2D-restricted cutaneous sensitivity responses.对半抗原4-羟基-3-硝基苯乙酰的特异性T细胞应答。VI. 介导H-2I限制性和H-2D限制性皮肤敏感反应的细胞中不同T细胞受体的证据。
J Exp Med. 1980 Dec 1;152(6):1554-62. doi: 10.1084/jem.152.6.1554.
8
Cell cooperation during in vivo anti-hapten antibody responses. V. Two synergistic Ly-1+23- helper T cells with distinctive specificities.体内抗半抗原抗体应答过程中的细胞协作。V. 两种具有独特特异性的协同性Ly-1⁺23⁻辅助性T细胞。
Eur J Immunol. 1980 Apr;10(4):231-6. doi: 10.1002/eji.1830100402.
9
Genetic control of a shared idiotype among antibodies directed to distinct specificities.针对不同特异性的抗体之间共享独特型的遗传控制。
J Exp Med. 1980 Jul 1;152(1):170-82. doi: 10.1084/jem.152.1.170.
10
T cell clones reactive with sperm whale myoglobin. Isolation of clones with specificity for individual determinants on myoglobin.与抹香鲸肌红蛋白反应的T细胞克隆。分离对肌红蛋白上单个决定簇具有特异性的克隆。
J Exp Med. 1981 Nov 1;154(5):1342-56. doi: 10.1084/jem.154.5.1342.

T细胞对半抗原修饰的自身免疫球蛋白的增殖反应：共轭特异性决定簇的识别

T-cell proliferative response to hapten-modified self-immunoglobulins: recognition of conjugate-specific determinants.

作者信息

Bikoff E

出版信息

Proc Natl Acad Sci U S A. 1982 Jul;79(13):4156-60. doi: 10.1073/pnas.79.13.4156.

DOI:10.1073/pnas.79.13.4156
PMID:6180436
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC346596/
Abstract

(4-Hydroxy-3-nitrophenyl)acetyl (NP)-modified BALB/c immunoglobulins were used as the immunogen for induction of a proliferative response in BALB/c mice. As is true for responses to other soluble antigens, proliferation was dependent on Lyt-1 cells and histocompatible radioresistant accessory cells. Lyt-1 cells directed against NP-modified self immunoglobulin are specific for the immunizing hapten NP. However, they do not recognize hapten per se. Rather, they see complex determinants comprised of both the hapten NP and the immunoglobulin self-carrier. Distinct specificities were created by coupling the same hapten to different monoclonal BALB/c antibody molecules or by attaching the hapten to the immunoglobulin self-carrier via a spacer molecule. It is proposed that determinants created by attaching haptens to self-immunoglobulin molecules are similar to those recognized by anti-idiotypic T cells.

摘要

（4-羟基-3-硝基苯基）乙酰基（NP）修饰的BALB/c免疫球蛋白被用作免疫原，以诱导BALB/c小鼠产生增殖反应。与对其他可溶性抗原的反应一样，增殖依赖于Lyt-1细胞和组织相容性抗辐射辅助细胞。针对NP修饰的自身免疫球蛋白的Lyt-1细胞对免疫原性半抗原NP具有特异性。然而，它们并不识别半抗原本身。相反，它们识别由半抗原NP和免疫球蛋白自身载体组成的复合决定簇。通过将相同的半抗原偶联到不同的单克隆BALB/c抗体分子上，或通过间隔分子将半抗原连接到免疫球蛋白自身载体上，可产生不同的特异性。有人提出，将半抗原连接到自身免疫球蛋白分子上所产生的决定簇与抗独特型T细胞所识别的决定簇相似。