对半抗原4-羟基-3-硝基苯乙酰的特异性T细胞应答。十二、抗独特型抑制性T细胞（Ts2）的精细特异性
Hapten-specific T cell responses to 4-hydroxy-3-nitrophenyl acetyl. XII. Fine specificity of anti-idiotypic suppressor T cells (Ts2).
作者信息
Sherr D H, Ju S T, Dorf M E
出版信息
J Exp Med. 1981 Nov 1;154(5):1382-9. doi: 10.1084/jem.154.5.1382.
Abstract
The fine specificity of anti-idiotypic, effector-phase suppressor T cells (Ts2) induced by the intravenous injection of syngeneic spleen cells covalently coupled with the 4-hydroxy-3-nitrophenyl acetyl (NP) hapten was studied in an in vitro plaque-forming cell system. By comparing the ability of these suppressor cells to bind monoclonal anti-NP antibodies that express different levels of serologically detected NPb idiotypic determinants, it was shown that anti-idiotypic suppressor T cells do not recognize the predominant NPb idiotypic determinants that are defined by serologic analysis. The implications for the possible expression and/or recognition of different sets of idiotypic determinants on T and B cells are discussed.
摘要
在体外空斑形成细胞系统中，研究了静脉注射与4-羟基-3-硝基苯基乙酰（NP）半抗原共价偶联的同基因脾细胞所诱导的抗独特型效应阶段抑制性T细胞（Ts2）的精细特异性。通过比较这些抑制性细胞结合表达不同血清学检测到的NPb独特型决定簇水平的单克隆抗NP抗体的能力，结果表明抗独特型抑制性T细胞不能识别血清学分析所定义的主要NPb独特型决定簇。文中讨论了T细胞和B细胞上不同组独特型决定簇可能的表达和/或识别的意义。
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本文引用的文献
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Hapten-specific T cell responses to 4-hydroxy-3-nitrophenyl acetyl. VII. Idiotype-specific suppression of plaque-forming cell responses.对半抗原4-羟基-3-硝基苯乙酰的特异性T细胞应答。VII. 独特型特异性对空斑形成细胞应答的抑制作用
J Exp Med. 1981 Mar 1;153(3):640-52. doi: 10.1084/jem.153.3.640.
2
Heavy chain variable region contribution to the NPb family of antibodies: somatic mutation evident in a gamma 2a variable region.重链可变区对NPb抗体家族的贡献：γ2a可变区中明显的体细胞突变。
Cell. 1981 Jun;24(3):625-37. doi: 10.1016/0092-8674(81)90089-1.
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Hapten-specific T cell responses to 4-hydroxy-3-nitrophenyl acetyl. IX. Characterization of Idiotype-specific effector-phase suppressor cells on plaque-forming cell responses in vitro.对半抗原4-羟基-3-硝基苯乙酰的特异性T细胞应答。IX. 体外针对空斑形成细胞应答的独特型特异性效应期抑制细胞的特性
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