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对半抗原4-羟基-3-硝基苯乙酰的特异性T细胞应答。十二、抗独特型抑制性T细胞（Ts2）的精细特异性

Hapten-specific T cell responses to 4-hydroxy-3-nitrophenyl acetyl. XII. Fine specificity of anti-idiotypic suppressor T cells (Ts2).

作者信息

Sherr D H, Ju S T, Dorf M E

出版信息

J Exp Med. 1981 Nov 1;154(5):1382-9. doi: 10.1084/jem.154.5.1382.

DOI:10.1084/jem.154.5.1382
PMID:6170718
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2186514/
Abstract

The fine specificity of anti-idiotypic, effector-phase suppressor T cells (Ts2) induced by the intravenous injection of syngeneic spleen cells covalently coupled with the 4-hydroxy-3-nitrophenyl acetyl (NP) hapten was studied in an in vitro plaque-forming cell system. By comparing the ability of these suppressor cells to bind monoclonal anti-NP antibodies that express different levels of serologically detected NPb idiotypic determinants, it was shown that anti-idiotypic suppressor T cells do not recognize the predominant NPb idiotypic determinants that are defined by serologic analysis. The implications for the possible expression and/or recognition of different sets of idiotypic determinants on T and B cells are discussed.

摘要

在体外空斑形成细胞系统中，研究了静脉注射与4-羟基-3-硝基苯基乙酰（NP）半抗原共价偶联的同基因脾细胞所诱导的抗独特型效应阶段抑制性T细胞（Ts2）的精细特异性。通过比较这些抑制性细胞结合表达不同血清学检测到的NPb独特型决定簇水平的单克隆抗NP抗体的能力，结果表明抗独特型抑制性T细胞不能识别血清学分析所定义的主要NPb独特型决定簇。文中讨论了T细胞和B细胞上不同组独特型决定簇可能的表达和/或识别的意义。

相似文献

1
Hapten-specific T cell responses to 4-hydroxy-3-nitrophenyl acetyl. XII. Fine specificity of anti-idiotypic suppressor T cells (Ts2).对半抗原4-羟基-3-硝基苯乙酰的特异性T细胞应答。十二、抗独特型抑制性T细胞（Ts2）的精细特异性
J Exp Med. 1981 Nov 1;154(5):1382-9. doi: 10.1084/jem.154.5.1382.
2
Hapten-specific T cell responses to 4-hydroxy-3-nitrophenyl acetyl. XIII. Characterization of a third T cell population involved in suppression of in vitro PFC responses.对半抗原4-羟基-3-硝基苯乙酰的特异性T细胞应答。十三。参与体外PFC反应抑制的第三种T细胞群体的特征。
J Immunol. 1982 Mar;128(3):1260-6.
3
Characterization of anti-idiotypic suppressor T cells (Tsid) induced after antigen priming.抗原致敏后诱导产生的抗独特型抑制性T细胞（Tsid）的特性分析。
J Immunol. 1984 Sep;133(3):1142-50.
4
Hapten-specific T cell responses to 4-hydroxy-3-nitrophenyl acetyl. VII. Idiotype-specific suppression of plaque-forming cell responses.对半抗原4-羟基-3-硝基苯乙酰的特异性T细胞应答。VII. 独特型特异性对空斑形成细胞应答的抑制作用
J Exp Med. 1981 Mar 1;153(3):640-52. doi: 10.1084/jem.153.3.640.
5
Hapten-specific T cell responses to 4-hydroxy-3-nitrophenyl acetyl. V. Role of idiotypes in the suppressor pathway.对半抗原4-羟基-3-硝基苯乙酰的特异性T细胞反应。V. 独特型在抑制途径中的作用。
J Exp Med. 1980 Jul 1;152(1):161-9. doi: 10.1084/jem.152.1.161.
6
Idiotypic and fine specificity analysis of a (4-hydroxy-3-nitrophenyl)acetyl (NP)-specific suppressor T cell hybridoma at the level of cell surface structures, isolated receptor material and functional suppressor factor.在细胞表面结构、分离的受体物质和功能性抑制因子水平上，对（4-羟基-3-硝基苯基）乙酰（NP）特异性抑制性T细胞杂交瘤进行独特型和精细特异性分析。
Eur J Immunol. 1983 Sep;13(9):711-9. doi: 10.1002/eji.1830130905.
7
Hapten-specific T cell responses to 4-hydroxy-3-nitrophenyl acetyl. IX. Characterization of Idiotype-specific effector-phase suppressor cells on plaque-forming cell responses in vitro.对半抗原4-羟基-3-硝基苯乙酰的特异性T细胞应答。IX. 体外针对空斑形成细胞应答的独特型特异性效应期抑制细胞的特性
J Exp Med. 1981 Jun 1;153(6):1445-56. doi: 10.1084/jem.153.6.1445.
8
Analysis of T cell hybridomas. III. Distinctions between two types of hapten-specific suppressor factors that affect plaque-forming cell responses.T细胞杂交瘤的分析。III. 影响噬斑形成细胞反应的两种类型的半抗原特异性抑制因子之间的区别。
J Exp Med. 1983 Feb 1;157(2):515-29. doi: 10.1084/jem.157.2.515.
9
Cross-reactivity of the NPa and NPb idiotypic responses of BALB/c and C57BL/6 mice to (4-hydroxy-3-nitrophenyl)acetyl (NP).BALB/c和C57BL/6小鼠针对（4-羟基-3-硝基苯基）乙酰基（NP）的NPa和NPb独特型反应的交叉反应性。
Eur J Immunol. 1982 Nov;12(11):935-42. doi: 10.1002/eji.1830121108.
10
Specific T helper and suppressor cells and factors induced in vitro to the hapten NP.在体外针对半抗原NP诱导产生的特异性辅助性T细胞、抑制性T细胞及因子。
Ann Immunol (Paris). 1980 May-Jun;131C(3):239-55.

引用本文的文献

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Chronic treatment with rabbit anti-mouse mu-chain antibody alters the characteristic immunoglobulin heavy-chain restriction of murine suppressor T-cell factors.用兔抗小鼠μ链抗体进行长期治疗会改变小鼠抑制性T细胞因子特征性的免疫球蛋白重链限制。
Proc Natl Acad Sci U S A. 1984 Jun;81(12):3846-50. doi: 10.1073/pnas.81.12.3846.
2
A mechanism responsible for the induction of H-2 restricted second order suppressor T cells.一种负责诱导H-2限制性二级抑制性T细胞的机制。
J Exp Med. 1983 Jun 1;157(6):1726-35. doi: 10.1084/jem.157.6.1726.
3
An idiotype-specific helper population that bears immunoglobulin, Ia, and Lyt-1 determinants.一种携带免疫球蛋白、Ia和Lyt-1决定簇的独特型特异性辅助细胞群体。
J Exp Med. 1984 Apr 1;159(4):1189-200. doi: 10.1084/jem.159.4.1189.
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Analysis of T cell hybridomas. IV. Characterization of inducible suppressor cell hybridomas.T细胞杂交瘤的分析。IV. 诱导性抑制细胞杂交瘤的特性
J Exp Med. 1983 May 1;157(5):1379-95. doi: 10.1084/jem.157.5.1379.
5
Analysis of T cell hybridomas. III. Distinctions between two types of hapten-specific suppressor factors that affect plaque-forming cell responses.T细胞杂交瘤的分析。III. 影响噬斑形成细胞反应的两种类型的半抗原特异性抑制因子之间的区别。
J Exp Med. 1983 Feb 1;157(2):515-29. doi: 10.1084/jem.157.2.515.
6
Modifications of the immune response induced by Histoplasma capsulatum products.荚膜组织胞浆菌产物诱导的免疫反应的改变。
Mycopathologia. 1990 Jan;109(1):1-9. doi: 10.1007/BF00436999.

本文引用的文献

1
Hapten-specific T cell responses to 4-hydroxy-3-nitrophenyl acetyl. VII. Idiotype-specific suppression of plaque-forming cell responses.对半抗原4-羟基-3-硝基苯乙酰的特异性T细胞应答。VII. 独特型特异性对空斑形成细胞应答的抑制作用
J Exp Med. 1981 Mar 1;153(3):640-52. doi: 10.1084/jem.153.3.640.
2
Heavy chain variable region contribution to the NPb family of antibodies: somatic mutation evident in a gamma 2a variable region.重链可变区对NPb抗体家族的贡献：γ2a可变区中明显的体细胞突变。
Cell. 1981 Jun;24(3):625-37. doi: 10.1016/0092-8674(81)90089-1.
3
Hapten-specific T cell responses to 4-hydroxy-3-nitrophenyl acetyl. IX. Characterization of Idiotype-specific effector-phase suppressor cells on plaque-forming cell responses in vitro.对半抗原4-羟基-3-硝基苯乙酰的特异性T细胞应答。IX. 体外针对空斑形成细胞应答的独特型特异性效应期抑制细胞的特性
J Exp Med. 1981 Jun 1;153(6):1445-56. doi: 10.1084/jem.153.6.1445.
4
Hapten-specific T cell responses to 4-hydroxy-3-nitrophenyl acetyl. VIII. Suppressor cell pathways in cutaneous sensitivity responses.对半抗原4-羟基-3-硝基苯乙酰的特异性T细胞反应。VIII. 皮肤敏感性反应中的抑制细胞途径。
J Exp Med. 1981 Apr 1;153(4):811-22. doi: 10.1084/jem.153.4.811.
5
Antigen- and receptor-driven regulatory mechanisms. IV. Idiotype-bearing I-J+ suppressor T cell factors induce second-order suppressor T cells which express anti-idiotypic receptors.抗原和受体驱动的调节机制。IV. 携带独特型的I-J+抑制性T细胞因子诱导表达抗独特型受体的二级抑制性T细胞。
J Exp Med. 1980 May 1;151(5):1183-95. doi: 10.1084/jem.151.5.1183.
6
Hapten-specific T cell responses to 4-hydroxy-3-nitrophenyl acetyl. V. Role of idiotypes in the suppressor pathway.对半抗原4-羟基-3-硝基苯乙酰的特异性T细胞反应。V. 独特型在抑制途径中的作用。
J Exp Med. 1980 Jul 1;152(1):161-9. doi: 10.1084/jem.152.1.161.
7
A mendelian idiotype is demonstrable in the heteroclitic anti-NP antibodies of the mouse.在小鼠的特异性抗核蛋白抗体中可证实孟德尔个体基因型。
Eur J Immunol. 1978 Feb;8(2):105-11. doi: 10.1002/eji.1830080207.
8
Analysis of V gene expression in the immune response by cell fusion.通过细胞融合分析免疫反应中的V基因表达。
Curr Top Microbiol Immunol. 1978;81:20-6. doi: 10.1007/978-3-642-67448-8_3.
9
Recognition of idiotypes in lymphocyte interactions. II. Antigen-independent cooperation between T and B lymphocytes that possess similar and complementary idiotypes.淋巴细胞相互作用中独特型的识别。II. 具有相似和互补独特型的T淋巴细胞与B淋巴细胞之间的抗原非依赖性合作。
Eur J Immunol. 1978 Dec;8(12):853-7. doi: 10.1002/eji.1830081206.
10
Idiotype suppression. III. Induction of unresponsiveness to sensitization with anti-idiotypic antibody: identification of the cell types tolerized in high zone and in low zone, suppressor cell-mediated, idiotype suppression.
Eur J Immunol. 1978 Dec;8(12):839-46. doi: 10.1002/eji.1830081204.