Harder W, Dijkhuizen L
Philos Trans R Soc Lond B Biol Sci. 1982 Jun 11;297(1088):459-80. doi: 10.1098/rstb.1982.0055.
In natural and man-made environments microorganisms often grow in the presence of a diversity of functionally similar substrates. The pattern of utilization of these mixed substrates is generally dependent upon their concentration. When substrates are present in high (not growth-limiting) concentrations, sequential utilization and diauxic growth is often observed and the substrate that supports the highest growth rate is utilized preferentially from the mixture. When the substrate concentrations are growth-limiting, simultaneous utilization of the various compounds present in the mixture appears to be the general response. Recent studies on mixed substrate utilization in both batch and continuous cultures have thrown light on the strategies of the control mechanisms that, in microbes, govern the utilization of the various substrates. But perhaps more importantly these studies have indicated the possible significance of mixed substrate utilization in microbial competition in nutrient-limited natural ecosystems.
在自然和人造环境中，微生物常常在多种功能相似的底物存在的情况下生长。这些混合底物的利用模式通常取决于它们的浓度。当底物以高浓度（非生长限制浓度）存在时，常常会观察到顺序利用和二次生长，并且混合物中支持最高生长速率的底物会被优先利用。当底物浓度成为生长限制因素时，混合物中各种化合物的同时利用似乎是普遍的反应。最近关于分批培养和连续培养中混合底物利用的研究揭示了微生物中控制各种底物利用的调控机制策略。但或许更重要的是，这些研究表明了混合底物利用在营养有限的自然生态系统中微生物竞争中可能具有的重要意义。
