不同方法测定前列腺癌中酸性磷酸酶的临床价值
Clinical value of different methods for determination of acid phosphatase in prostatic cancer.
作者信息
Flüchter S H, Bichler K H, Harzmann R, Reuter M A, Mildner A
出版信息
Urol Int. 1982;37(2):79-86. doi: 10.1159/000280801.
The availability of a radioimmunoassay (RIA) and an enzyme immunoassay (EIA) for the prostate specific acid phosphatase required a study to compare these techniques with the conventional colorimetric assay. Our study is based on examinations of 188 normal persons and 136 patients with carcinoma of the prostate. The advantage of the immunologic methods - RIA and EIA - lies in their stable immunologic activity and their high specificity. However, RIA and EIA are not screening methods for incidental carcinoma because of their low sensitivity for stage-A tumors. Their good sensitivity at lower ranges of concentration makes them suitable for checking the course of a prostatic carcinoma during therapy. The level of prostatic acid phosphatase may allow conclusions about intra-or extracapsular growth of the prostatic carcinoma.
前列腺特异性酸性磷酸酶放射免疫测定法（RIA）和酶免疫测定法（EIA）的出现，需要开展一项研究，以将这些技术与传统比色测定法进行比较。我们的研究基于对188名正常人和136名前列腺癌患者的检查。免疫方法（RIA和EIA）的优势在于其稳定的免疫活性和高特异性。然而，RIA和EIA并非偶然癌的筛查方法，因为它们对A期肿瘤的敏感性较低。它们在较低浓度范围内具有良好的敏感性，这使得它们适用于在治疗期间检查前列腺癌的病程。前列腺酸性磷酸酶水平可能有助于推断前列腺癌的包膜内或包膜外生长情况。
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