Pontes J E, Choe B K, Rose N R, Ercole C, Pierce J M
J Urol. 1981 Sep;126(3):363-5. doi: 10.1016/s0022-5347(17)54528-0.
Evaluation of serum acid phosphatase by 3 immunochemical methods (radioimmunoassay, counterimmunoelectrophoresis and immunoenzymoassay) was done in 3 groups of patients. In 42 patients wit stage D prostatic carcinoma a comparison of serum acid phosphatase determination by colorimetric assay and the 3 immunochemical methods in samples obtained before and after initiation of therapy showed an excellent correlation among the assays. Presently, we see no advantage of the immunochemical methods over the colorimetric assay in this group of patients. Among 100 patients studied in a blind fashion to detect those with unsuspected prostatic carcinoma no such cases were found. In the last group of patients with localized prostatic carcinoma staged surgically by pelvic lymphadenectomy the only elevations of serum acid phosphatase were observed in patients with extraprostatic involvement.
采用3种免疫化学方法（放射免疫测定法、对流免疫电泳法和免疫酶测定法）对3组患者的血清酸性磷酸酶进行了评估。在42例D期前列腺癌患者中，对比了比色法与3种免疫化学方法对治疗开始前后采集样本中血清酸性磷酸酶的测定结果，结果显示这些测定方法之间具有良好的相关性。目前，我们认为在这组患者中，免疫化学方法对比色法并无优势。在对100例患者进行盲法研究以检测未被怀疑患有前列腺癌的患者时，未发现此类病例。在最后一组通过盆腔淋巴结清扫术进行手术分期的局限性前列腺癌患者中，仅在有前列腺外受累的患者中观察到血清酸性磷酸酶升高。
