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[长期食用加药饲料后仔猪的药物毒性]

[Drug toxicity in piglets following long-term consumption of medicated feed].

作者信息

van de Kerk P

出版信息

Tijdschr Diergeneeskd. 1985 Mar 1;110(5):181-4.

PMID:3983948
Abstract

The effect of the addition of various drugs to the feed on the performance of recent weaned piglets was studied. The following procedures were examined: no additive, 50 ppm of carbadox, 50 ppm of carbadox plus 400 ppm of furazolidone, 50 ppm of carbadox plus 22 ppm of lincomycin plus 22 ppm of spectinomycin, 400 ppm of furazolidone and 22 ppm of lincomycin plus 22 ppm of spectinomycin. Each treatment was carried out in ten groups of eight piglets. The trials were continued from the fifth to the eighth week of life. Addition of lincomycin and spectinomycin improved both growth and feed conversion. Combined administration of lincomycin and spectinomycin with carbadox resulted in the best performance. Supplementation of carbadox alone did not produce any beneficial effects. Addition of 400 ppm of furazolidone resulted in a significant depression of growth. Combined administration of 400 ppm furazolidone and 50 ppm of carbadox resulted in the poorest performance. The growth depressing effect of this combined treatment was observed as early as the first two weeks of the experiment. The animals undergoing this treatment showed a greyish-white colour of the skin and very hard stools.

摘要

研究了在饲料中添加各种药物对刚断奶仔猪生产性能的影响。研究了以下几种处理方式:不添加任何添加剂、添加50 ppm卡巴氧、添加50 ppm卡巴氧加400 ppm呋喃唑酮、添加50 ppm卡巴氧加22 ppm林可霉素加22 ppm壮观霉素、添加400 ppm呋喃唑酮以及添加22 ppm林可霉素加22 ppm壮观霉素。每种处理方式设置十组,每组八头仔猪。试验从仔猪出生后第五周持续至第八周。添加林可霉素和壮观霉素可同时改善生长性能和饲料转化率。林可霉素和壮观霉素与卡巴氧联合使用时生产性能最佳。单独添加卡巴氧未产生任何有益效果。添加400 ppm呋喃唑酮导致生长显著受抑。400 ppm呋喃唑酮与50 ppm卡巴氧联合使用时生产性能最差。早在实验的前两周就观察到了这种联合处理对生长的抑制作用。接受这种处理的仔猪皮肤呈灰白色,粪便非常干结。

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