Van Binsbergen C J, Odink J, Van der Beek E J, Westenberg H M, Bennink H J
Department of Obstetrics and Gynecology, University Hospital, Utrecht, Netherlands.
Psychosom Med. 1991 Jul-Aug;53(4):440-52. doi: 10.1097/00006842-199107000-00009.
To investigate the sympathetic response in anorexia nervosa (AN) patients to stimuli occurring in normal life, biogenic amines were studied in 10 female outpatients. As control groups 10 lean and 10 normal weight healthy female subjects were included. It was hypothesized that the lean control group would have intermediate values between the AN patients and the normal weight controls. The AN patients and the lean controls had a mean underweight of 33.1% and 13.7%, respectively. For the excretion in 24-hr urine, differences among the groups were observed for several compounds, unexpectedly the values being lowest for the patients and highest for the lean controls. Furthermore, the lean controls had a higher excretion of a number of compounds in diurnal than in nocturnal urine, whereas this effect was absent or reversed for the AN patients and intermediate for the normal weight controls. Plasma norepinephrine was highest in the patients and lowest in the lean controls. The catecholamine response to postural changes and physical exercise did not differ among the groups. The results obtained indicate neither a (linear) relationship between underweight and the metabolism of biogenic amines nor a disturbed response to sympathetic stimulation in AN, but suggest an altered metabolism of biogenic amines in patients suffering from AN.
为了研究神经性厌食症（AN）患者对正常生活中出现的刺激的交感神经反应，对10名女性门诊患者的生物胺进行了研究。作为对照组，纳入了10名消瘦和10名体重正常的健康女性受试者。研究假设是消瘦对照组的数值将介于AN患者和体重正常对照组之间。AN患者和消瘦对照组的平均体重不足分别为33.1%和13.7%。对于24小时尿液排泄，观察到几组之间几种化合物存在差异，出乎意料的是，患者的值最低，消瘦对照组的值最高。此外，消瘦对照组日间尿液中多种化合物的排泄量高于夜间，而AN患者不存在这种效应或出现相反情况，体重正常对照组则处于中间状态。血浆去甲肾上腺素在患者中最高，在消瘦对照组中最低。体位变化和体育锻炼引起的儿茶酚胺反应在几组之间没有差异。所得结果既未表明体重不足与生物胺代谢之间存在（线性）关系，也未表明AN患者对交感神经刺激的反应紊乱，但提示AN患者生物胺代谢发生了改变。
