Reinsmoen N L, Bach F H
Hum Immunol. 1982 Jun;4(3):249-58. doi: 10.1016/0198-8859(82)90040-4.
In order to investigate the HLA-D clusters associated with DR4, 54 DR4-positive, Dw4- and Dw10-negative responders, together with selected Dw4- or Dw10-positive responders, were tested with 22 HTCs that define DR4-associated D specificities. The results are consistent with previous data defining four distinct D clusters--Dw4, Dw10, DB3, and DYT--and have identified a new cluster provisionally termed LD40. In addition, the DB3 cluster is complex and appears to give typing response patterns overlapping those of the KT2 cluster originally defined as being associated with DR4 in Japanese populations. Of 116 DR4-positive haplotypes tested, 44% typed as Dw4, 18% were LD40, 16% were Dw10, 9% were DB3, 3% were DYT, and 10% gave no typing response to the HTCs defining any of these clusters. These studies are informative not only in defining the DR4-associated D clusters and in supporting the concept that D and DR cannot be considered identical but also in emphasizing the complexity of the D region.
为了研究与DR4相关的HLA - D簇，对54名DR4阳性、Dw4和Dw10阴性反应者以及选定的Dw4或Dw10阳性反应者，用22种定义与DR4相关的D特异性的HTC进行检测。结果与先前定义四个不同D簇（Dw4、Dw10、DB3和DYT）的数据一致，并确定了一个新的簇，暂称为LD40。此外，DB3簇很复杂，其分型反应模式似乎与最初在日本人群中定义为与DR4相关的KT2簇的模式重叠。在检测的116个DR4阳性单倍型中，44%分型为Dw4，18%为LD40，16%为Dw10，9%为DB3，3%为DYT，10%对定义这些簇中任何一个的HTC没有分型反应。这些研究不仅有助于定义与DR4相关的D簇，支持D和DR不能被视为相同的概念，还强调了D区域的复杂性。
