HLA - DB3：白种人中与HLA - DR4相关的一种新的HLA - D抗原的群体分布及家系研究。

HLA-DB3: population distribution and family studies of a new HLA-D antigen associated with HLA-D antigen associated with HLA-DR4 in Caucasoids.

作者信息

Jaraquemada D, Ollier W, Okoye R C, Sachs J A, Festenstein H, Grosse-Wilde H

出版信息

Tissue Antigens. 1983 Nov;22(5):315-25. doi: 10.1111/j.1399-0039.1983.tb02260.x.

DOI:10.1111/j.1399-0039.1983.tb02260.x

PMID:6419385

Abstract

On the basis of studies with 6 HTCs in four different families the new cluster DB3 identified in the 8th Workshop can be considered an established specificity of the HLA-D series. In 112 healthy Caucasoids resident in South East England the frequency of this antigen was 2.6% similar to the frequency found in 142 Caucasoid patients with rheumatoid arthritis. The frequency in 54 unrelated Chinese individuals from Shanghai and of 120 Nigerians was 7.5% and 3%, respectively. All Caucasoid individuals who were DB3 were also DR4 whereas no such association was found in the two other population groups.

摘要

基于对四个不同家族中6个HTC的研究，在第8次研讨会上鉴定出的新簇DB3可被视为HLA - D系列已确定的特异性。在居住在英格兰东南部的112名健康白种人中，该抗原的频率为2.6%，与142名患类风湿性关节炎的白种人患者中发现的频率相似。来自上海的54名无亲缘关系的中国人和120名尼日利亚人的频率分别为7.5%和3%。所有DB3阳性的白种人个体也都是DR4阳性，而在其他两个人群组中未发现这种关联。