Vântu A, Bălănescu I, Stafidov N, Voiculeţ N
Med Interne. 1982 Apr-Jun;20(2):151-5.
To find the marker value of the carcinoembryonic antigen, alpha-fetoprotein (AFP) and immunoglobulin levels in patients with breast cancer, stages I or II, these parameters were determined in 94 patients devided into two groups: group A of 57 patients operated on for extirpation of the tumor without preoperative treatment and group B of 37 patients subjected to cobalto-therapy prior to operation then having the tumor extirpated. In the first group the determinations were performed before operation, at 14 days, and 2 months, respectively after the operation. In the second group 5 determinations were performed: before cobalto-therapy, after therapy, before the operation, at 15 days and 2 months, respectively after the operation. CEA and AFP were determined by the RIA tests and the immunoglobulins by immunodiffusion. The results showed that in 7 out of 37 cases the levels of CEA were significantly raised before and after therapy sometimes reaching values as high as 1000-3000 ng/nl while AFP was not influenced at all by breast tumors. The immunoglobulin values were also uninfluenced by the disease, but in certain cases of breast cancer IgA reached values of 300-500 IU/ml. It is assumed that since the patients who presented high CEA values had also an unfavourable evolution of the disease, determination of this antigen might also have a predictive value.
为了找出Ⅰ期或Ⅱ期乳腺癌患者癌胚抗原、甲胎蛋白（AFP）及免疫球蛋白水平的标记值，对94例患者的这些参数进行了测定。这些患者被分为两组：A组57例，未接受术前治疗直接进行肿瘤切除手术；B组37例，术前接受钴治疗，然后进行肿瘤切除。在第一组中，分别在手术前、术后14天和术后2个月进行测定。在第二组中进行了5次测定：钴治疗前、治疗后、手术前、术后15天和术后2个月。癌胚抗原（CEA）和甲胎蛋白（AFP）通过放射免疫分析测试测定，免疫球蛋白通过免疫扩散测定。结果显示，在37例患者中，有7例患者治疗前后CEA水平显著升高，有时高达1000 - 3000 ng/nl，而AFP完全不受乳腺肿瘤影响。免疫球蛋白值也不受该疾病影响，但在某些乳腺癌病例中，IgA达到300 - 500 IU/ml。据推测，由于CEA值高的患者病情发展也不利，因此该抗原的测定可能也具有预测价值。
